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Gene Review

Dap3  -  death associated protein 3

Mus musculus

Synonyms: 28S ribosomal protein S29, mitochondrial, 4921514D13Rik, DAP-3, Death-associated protein 3, MRP-S29, ...
 
 
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Disease relevance of Dap3

 

High impact information on Dap3

  • DAP-3 mediated apoptosis was shown to depend on a functional P-loop [2].
  • These data identify mDAP-3 as one of the first proapoptotic factors in the mitochondrial matrix and provide evidence for a critical, evolutionary conserved role of members of the DAP-3 protein family for mitochondrial biogenesis [2].
  • Loss of mitochondrial DNA in yDAP-3 was partially prevented by transfection of the yDAP-3 deficient mutant with mDAP-3, indicating functional complementation by murine DAP-3 in the yeast system [2].
  • These results suggest that Tfg and Dap3 function downstream of Ikaros and may be involved in radiation-induced lymphomagenesis [1].
  • Studies of cultured cells from dap3-/- embryos confirmed a role in apoptosis induced by stimuli that trigger the extrinsic (TNFalpha, TRAIL, anti-Fas antibody) but not intrinsic (mitochondrial) cell death pathway [3].
 

Biological context of Dap3

  • Death-associated protein-3 (DAP3) is a GTP binding protein previously implicated in both intramitochondrial protein synthesis and apoptosis [3].
  • Levels of cytochrome c oxidase-I, a protein encoded in the mitochondrial genome, were reduced in dap3-/- embryos, consistent with a role for DAP3 in intramitochondrial protein synthesis [3].
 

Anatomical context of Dap3

References

  1. Altered expression of Tfg and Dap3 in Ikaros-defective T-cell lymphomas induced by X-irradiation in B6C3F1 mice. Yasumura, K., Sugimura, I., Igarashi, K., Kakinuma, S., Nishimura, M., Doi, M., Shimada, Y. Br. J. Haematol. (2004) [Pubmed]
  2. The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins. Berger, T., Brigl, M., Herrmann, J.M., Vielhauer, V., Luckow, B., Schlöndorff, D., Kretzler, M. J. Cell. Sci. (2000) [Pubmed]
  3. Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis. Kim, H.R., Chae, H.J., Thomas, M., Miyazaki, T., Monosov, A., Monosov, E., Krajewska, M., Krajewski, S., Reed, J.C. FASEB J. (2007) [Pubmed]
 
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