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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mgat5  -  mannosyl (alpha-1,6-)-glycoprotein beta-1...

Rattus norvegicus

Synonyms: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A, Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, GNT-V, GlcNAc-T V, Mannoside acetylglucosaminyltransferase 5, ...
 
 
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Disease relevance of Mgat5

  • Also, a GlcNAc-T V-deficient, mutant lymphoma cell line, PHAR2.1, was found to express mRNAs which are larger than the normal mRNAs, possible due to an insertion or aberrant splicing, resulting in a defective mRNA [1].
 

High impact information on Mgat5

  • A cDNA clone for the complete coding sequence for alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase V (GlcNAc-T V, EC 2.4.1.155) was isolated and expressed in COS-7 cells [2].
  • Degenerate oligonucleotide primers for polymerase chain reaction were synthesized based on the amino acid sequence of three tryptic peptides isolated from affinity-purified GlcNAc-T V [2].
  • The GlcNAc-T V mRNA is expressed in different amounts in the various mouse tissues, with the greatest amount observed in brain, followed by thymus, kidney, lung, intestine, heart and stomach, and no transcripts detected in liver or skeletal muscle [1].
 

Anatomical context of Mgat5

  • In order to characterize the regulation of GlcNAc-T V at the molecular level, we have examined the expression of Glc-NAc-T V mRNAs in a number of mouse tissues and in several human and rodent cell lines [1].

References

  1. Expression of N-acetylglucosaminyltransferase V mRNA in mammalian tissues and cell lines. Perng, G.S., Shoreibah, M., Margitich, I., Pierce, M., Fregien, N. Glycobiology (1994) [Pubmed]
  2. Isolation, characterization, and expression of a cDNA encoding N-acetylglucosaminyltransferase V. Shoreibah, M., Perng, G.S., Adler, B., Weinstein, J., Basu, R., Cupples, R., Wen, D., Browne, J.K., Buckhaults, P., Fregien, N. J. Biol. Chem. (1993) [Pubmed]
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