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Gene Review

Slc9a3r2  -  solute carrier family 9 (sodium/hydrogen...

Mus musculus

Synonyms: 0610011L07Rik, 1200011K07Rik, 2010007A20Rik, E3karp, NHE3 kinase A regulatory protein E3KARP, ...
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High impact information on Slc9a3r2


Anatomical context of Slc9a3r2

  • Although NHERF-2 can be detected weakly in the microvilli, it is expressed predominantly at the base of the microvilli in the vesicle-rich domain [3].
  • Using the farwestern protein-blotting technique and recombinant fusion proteins containing the Sry Q-rich domain as probes, three Sry interactive proteins of 94, 32 and 28 kDa apparent molecular weight (Sip-1, -2 and -3 respectively) were consistently detected in adult testis [4].
  • This study reports production of somites with roughly half rostro-caudal length in homozygous Sip1 (Smad-interacting protein 1) knockout mouse embryos [5].
  • Quantitative analysis of the subcellular distribution of NHERF-2 immunostaining in four brain structures, cerebral cortex, hippocampus, striatum, and cerebellar cortex, showed that NHERF-2 was expressed mainly in astrocytic processes but was also sometimes observed in both pre- and postsynaptic neuronal elements [2].

Physical interactions of Slc9a3r2

  • In expression systems and in yeast, Na/H exchanger regulatory factor (NHERF)-1 and NHERF-2 have been demonstrated to interact with the renal brush border membrane proteins NHE3 and Npt2 [3].

Analytical, diagnostic and therapeutic context of Slc9a3r2


  1. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Shenolikar, S., Voltz, J.W., Minkoff, C.M., Wade, J.B., Weinman, E.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Astrocytic and neuronal localization of the scaffold protein Na+/H+ exchanger regulatory factor 2 (NHERF-2) in mouse brain. Paquet, M., Kuwajima, M., Yun, C.C., Smith, Y., Hall, R.A. J. Comp. Neurol. (2006) [Pubmed]
  3. Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. Wade, J.B., Liu, J., Coleman, R.A., Cunningham, R., Steplock, D.A., Lee-Kwon, W., Pallone, T.L., Shenolikar, S., Weinman, E.J. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  4. In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. Zhang, J., Coward, P., Xian, M., Lau, Y.F. Int. J. Dev. Biol. (1999) [Pubmed]
  5. Involvement of SIP1 in positioning of somite boundaries in the mouse embryo. Maruhashi, M., Van De Putte, T., Huylebroeck, D., Kondoh, H., Higashi, Y. Dev. Dyn. (2005) [Pubmed]
  6. The PDZ Scaffold NHERF-2 Interacts with mGluR5 and Regulates Receptor Activity. Paquet, M., Asay, M.J., Fam, S.R., Inuzuka, H., Castleberry, A.M., Oller, H., Smith, Y., Yun, C.C., Traynelis, S.F., Hall, R.A. J. Biol. Chem. (2006) [Pubmed]
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