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Gene Review

Lpar3  -  lysophosphatidic acid receptor 3

Rattus norvegicus

Synonyms: Edg7, LPA receptor 3, LPA-3, Lpa3, Lysophosphatidic acid receptor 3, ...
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Disease relevance of Edg7

  • Pertussis toxin, the LPA1/LPA3 receptor-selective antagonist dioctylglycerol pyrophosphate, the myristoylated inhibitory pseudosubstrate peptide of protein kinase A (PKI), Wortmannin and PD98059 abolished the neurite-promoting effect. cPA elicited a sustained activation of extracellular signal-related kinases (ERK) 1/2 and Akt [1].

Anatomical context of Edg7


Associations of Edg7 with chemical compounds

  • The levels of mRNA of LPA1 and S1P receptors was reduced by overnight exposure to S1P, while the same treatment significantly up-regulated the level of LPA3 mRNA [3].

Other interactions of Edg7

  • Initially, we observed that OECs expressed the genes for LPA1, LPA2, and LPA3 receptors [4].


  1. Cyclic phosphatidic acid elicits neurotrophin-like actions in embryonic hippocampal neurons. Fujiwara, Y., Sebök, A., Meakin, S., Kobayashi, T., Murakami-Murofushi, K., Tigyi, G. J. Neurochem. (2003) [Pubmed]
  2. Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes. Kim, M.K., Lee, H.Y., Park, K.S., Shin, E.H., Jo, S.H., Yun, J., Lee, S.W., Yoo, Y.H., Lee, Y.S., Baek, S.H., Bae, Y.S. Biochem. Pharmacol. (2005) [Pubmed]
  3. Microglial activation state and lysophospholipid acid receptor expression. Tham, C.S., Lin, F.F., Rao, T.S., Yu, N., Webb, M. Int. J. Dev. Neurosci. (2003) [Pubmed]
  4. Lysophosphatidic acid regulates the proliferation and migration of olfactory ensheathing cells in vitro. Yan, H., Lu, D., Rivkees, S.A. Glia (2003) [Pubmed]
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