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SLC2A11  -  solute carrier family 2 (facilitated...

Homo sapiens

Synonyms: GLUT-10, GLUT-11, GLUT10, GLUT11, Glucose transporter type 10, ...
 
 
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Disease relevance of SLC2A11

  • GLUT10 deficiency is associated with upregulation of the TGFbeta pathway in the arterial wall, a finding also observed in Loeys-Dietz syndrome, in which aortic aneurysms associate with arterial tortuosity [1].
  • Our results indicate that GLUT11 immunoreactivity, in contrast to that of GLUT4, is expressed exclusively in slow-twitch muscle fibres and is unaffected by physiological and pathophysiological conditions except in primary myopathy [2].
 

High impact information on SLC2A11

  • Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome [1].
  • The identification of a glucose transporter gene responsible for altered arterial morphogenesis is notable in light of the previously suggested link between GLUT10 and type 2 diabetes [1].
  • Here we demonstrate that separate exons 1 (exon 1A, exon 1B, and exon 1C) of the SLC2A11 gene generate mRNAs of three GLUT11 variants (GLUT11-A, GLUT11-B, and GLUT11-C) that differ in the amino acid sequence of their N-termini [3].
  • GLUT11 (SLC2A11) is a class II sugar transport facilitator which exhibits highest similarity with the fructose transporter GLUT5 (about 42%) [3].
  • When expressed in Xenopus oocytes, all three GLUT11 isoforms transport glucose and fructose but not galactose [3].
 

Biological context of SLC2A11

  • The human GLUT11 gene (SLC2A11) consists of 12 exons and is located on chromosome 22q11 [4].
  • We isolated a member of the facilitative glucose transporter (GLUT) gene family (GLUT11; SLC2A11 as a HGMW-approved symbol) based on the analysis of a human genomic BAC clone KB1125A3 located on band q11.2 of human chromosome 22 [5].
  • Transfection of COS-7 cells with GLUT11 cDNA significantly increased the glucose-transport activity reconstituted from membrane extracts as well as the specific binding of the sugar-transporter ligand cytochalasin B [4].
 

Anatomical context of SLC2A11

  • Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle [4].
 

Associations of SLC2A11 with chemical compounds

 

Other interactions of SLC2A11

 

Analytical, diagnostic and therapeutic context of SLC2A11

References

  1. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. Coucke, P.J., Willaert, A., Wessels, M.W., Callewaert, B., Zoppi, N., De Backer, J., Fox, J.E., Mancini, G.M., Kambouris, M., Gardella, R., Facchetti, F., Willems, P.J., Forsyth, R., Dietz, H.C., Barlati, S., Colombi, M., Loeys, B., De Paepe, A. Nat. Genet. (2006) [Pubmed]
  2. GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. Gaster, M., Handberg, A., Schürmann, A., Joost, H.G., Beck-Nielsen, H., Schrøder, H.D. Pflugers Arch. (2004) [Pubmed]
  3. Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. Scheepers, A., Schmidt, S., Manolescu, A., Cheeseman, C.I., Bell, A., Zahn, C., Joost, H.G., Schürmann, A. Mol. Membr. Biol. (2005) [Pubmed]
  4. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Doege, H., Bocianski, A., Scheepers, A., Axer, H., Eckel, J., Joost, H.G., Schürmann, A. Biochem. J. (2001) [Pubmed]
  5. Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. Sasaki, T., Minoshima, S., Shiohama, A., Shintani, A., Shimizu, A., Asakawa, S., Kawasaki, K., Shimizu, N. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Wu, X., Li, W., Sharma, V., Godzik, A., Freeze, H.H. Mol. Genet. Metab. (2002) [Pubmed]
  7. Studies of relationships between the GLUT10 Ala206Thr polymorphism and impaired insulin secretion. Rose, C.S., Andersen, G., Hamid, Y.H., Glümer, C., Drivsholm, T., Borch-Johnsen, K., Jørgensen, T., Pedersen, O., Hansen, T. Diabet. Med. (2005) [Pubmed]
 
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