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Gene Review:

Hspbp1 - HSPA (heat shock 70kDa) binding protein,...

Mus musculus

Synonyms: 1500019G21Rik, Heat shock protein-binding protein 1, Hsp70-binding protein 1, Hsp70-interacting protein 1, HspBP1, ...

Raynes, D.A. et al., Zhang, C. et al., Kanelakis, K.C. et al.

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Disease relevance of 1500019G21Rik

In this report, we show that HspBP1 levels are elevated in two mouse tumor models, 3LL cells (Lewis Lung carcinoma) and neuroblastoma tumors [1].

High impact information on 1500019G21Rik

Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery [2].
CHIP (carboxyl terminus of Hsp70-interacting protein) is a cochaperone/ubiquitin ligase that integrates the response to stress at multiple levels [3].
Increased expression of the Hsp70 cochaperone HspBP1 in tumors [1].

Anatomical context of 1500019G21Rik

The amounts of HspBP1 and Hsp70 in selected tissues, tumors and a rabbit reticulocyte lysate were determined using Western blots [1].

References

Increased expression of the Hsp70 cochaperone HspBP1 in tumors. Raynes, D.A., Graner, M.W., Bagatell, R., McLellan, C., Guerriero, V. Tumour Biol. (2003) [Pubmed]
Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery. Kanelakis, K.C., Morishima, Y., Dittmar, K.D., Galigniana, M.D., Takayama, S., Reed, J.C., Pratt, W.B. J. Biol. Chem. (1999) [Pubmed]
CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice. Zhang, C., Xu, Z., He, X.R., Michael, L.H., Patterson, C. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]

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