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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Sln  -  sarcolipin

Mus musculus

Synonyms: 2310045A07Rik, Sarcolipin
 
 
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Disease relevance of Sln

 

High impact information on Sln

  • Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation [2].
  • Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice [3].
  • Sarcolipin retention in the endoplasmic reticulum depends on its C-terminal RSYQY sequence and its interaction with sarco(endo)plasmic Ca(2+)-ATPases [4].
  • The role of sarcolipin (SLN) in cardiac physiology was critically evaluated by generating a transgenic (TG) mouse model in which the SLN to sarco(endoplasmic)reticulum (SR) Ca(2+) ATPase (SERCA) ratio was increased in the ventricle [5].
  • Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility [5].
 

Biological context of Sln

 

Anatomical context of Sln

  • In humans, sarcolipin mRNA was also expressed in the atria but not detected in the ventricles, although sarcolipin expression was most abundant in skeletal muscle [6].
  • TAC significantly decreased the expression of sarcolipin, SERCA2a, and phospholamban mRNAs in the left atrium (LA) than those in the right atrium (RA) [7].
 

Analytical, diagnostic and therapeutic context of Sln

  • Northern blot analysis revealed that the expression of mouse sarcolipin mRNA was most abundant in the atria and was undetectable in the ventricles, indicating an atrial chamber-specific expression pattern [6].

References

  1. Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium. Minamisawa, S., Uemura, N., Sato, Y., Yokoyama, U., Yamaguchi, T., Inoue, K., Nakagome, M., Bai, Y., Hori, H., Shimizu, M., Mochizuki, S., Ishikawa, Y. FEBS Lett. (2006) [Pubmed]
  2. Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation. Gramolini, A.O., Trivieri, M.G., Oudit, G.Y., Kislinger, T., Li, W., Patel, M.M., Emili, A., Kranias, E.G., Backx, P.H., Maclennan, D.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Asahi, M., Otsu, K., Nakayama, H., Hikoso, S., Takeda, T., Gramolini, A.O., Trivieri, M.G., Oudit, G.Y., Morita, T., Kusakari, Y., Hirano, S., Hongo, K., Hirotani, S., Yamaguchi, O., Peterson, A., Backx, P.H., Kurihara, S., Hori, M., MacLennan, D.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Sarcolipin retention in the endoplasmic reticulum depends on its C-terminal RSYQY sequence and its interaction with sarco(endo)plasmic Ca(2+)-ATPases. Gramolini, A.O., Kislinger, T., Asahi, M., Li, W., Emili, A., MacLennan, D.H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility. Babu, G.J., Bhupathy, P., Petrashevskaya, N.N., Wang, H., Raman, S., Wheeler, D., Jagatheesan, G., Wieczorek, D., Schwartz, A., Janssen, P.M., Ziolo, M.T., Periasamy, M. J. Biol. Chem. (2006) [Pubmed]
  6. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. Minamisawa, S., Wang, Y., Chen, J., Ishikawa, Y., Chien, K.R., Matsuoka, R. J. Biol. Chem. (2003) [Pubmed]
  7. Mechanical stress-dependent transcriptional regulation of sarcolipin gene in the rodent atrium. Shimura, M., Minamisawa, S., Yokoyama, U., Umemura, S., Ishikawa, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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