The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Trim13  -  tripartite motif-containing 13

Mus musculus

Synonyms: 3110001L12Rik, CAR, E3 ubiquitin-protein ligase TRIM13, LEU5, RNF77, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Trim13

  • A series of deltorphin (DLT: Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2) analogs in which Leu5 and/or Met6 were mainly replaced by t-Leu(Tle) and/or N alpha-alkylated glycine were synthesized and examined for their receptor binding properties and in vitro bioactivities by guinea pig ileum (GPI) and mouse vas deferens (MVD) assays [1].
  • Leu5 and the interdependence of Leu5 and D-Ala2 are of importance for the selectivity of dalargin for mu-opioid receptors [2].
  • From observations on a considerable number of [Leu5] enkephalin analogues, it has been concluded that [D-Pen2, D-Pen5] enkephalin and [D-Pen2, L-Pen5] enkephalin are the most selective delta-agonists and that N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH is the most selective antagonist (Aib = alpha-aminoisobutyric acid) [3].
  • Saturation binding assays using [3H][D-Pen5]enkephalin (DPDPE) or [3H][D-Ser2, Leu5, Thr6]enkephalin (DSLET) gave similar binding capacities (Bmax) [4].
  • Accordingly, antiserum raised against the glutaraldehyde-induced conjugate specifically recognized the peptide carboxyl terminus and allowed immunohistochemical distinction of the octapeptide from other closely related opioid peptides, such as Leu5- and Met5-enkephalin, Met5-enkephalin-Arg6-Phe7, and Phe1-Met2-Arg3-Phe4-NH2 [5].
 

Anatomical context of Trim13

  • A rat X mouse hybridoma line producing a monoclonal antibody against leu5 enkephalin has been obtained [6].
  • The selective delta-opiate agonists D-Ser2, Leu5, Thr6-enkephalin (DSLET), D-Ala2, D-Leu5-enkephalin and D-Pen2, D-Pen5-enkephalin caused inhibition of the cholinergic contraction produced by transmural stimulation of the rat isolated jejunum [7].
  • This monoclonal antibody has been used in a radioimmunoassay to determine leu5 enkephalin like immunoreactive material present in rat brain and hypothalamus [6].
 

Associations of Trim13 with chemical compounds

  • The results suggest that the introduction of trifluoromethyl group in Leu5 results in the alternation of the opioid activity and receptor selectivity [8].
 

Analytical, diagnostic and therapeutic context of Trim13

  • Bioassay of the synthetic analogs for analgesic activity by the tail-flick method showed the D-Leu2 analog to be 48% as potent as betah-endorphin while the Ala2, D-Lys2, Leu5, and [D-Ala2, D-Leu5] analogs were 8 to 17% as active [9].

References

  1. Novel deltorphin heptapeptide analogs with potent delta agonist, delta antagonist, or mixed mu antagonist/delta agonist properties. Sasaki, Y., Chiba, T. J. Med. Chem. (1995) [Pubmed]
  2. Activity profiles of dalargin and its analogues in mu-, delta- and kappa-opioid receptor selective bioassays. Pencheva, N., Pospisek, J., Hauzerova, L., Barth, T., Milanov, P. Br. J. Pharmacol. (1999) [Pubmed]
  3. Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor. Corbett, A.D., Gillan, M.G., Kosterlitz, H.W., McKnight, A.T., Paterson, S.J., Robson, L.E. Br. J. Pharmacol. (1984) [Pubmed]
  4. Determination of delta-opioid in NG108-15 cells. Ho, B.Y., Holmes, B.B., Zhao, J., Fujimoto, J. Eur. J. Pharmacol. (1997) [Pubmed]
  5. Immunohistochemistry of enkephalins: model studies on hapten-carrier conjugates and fixation methods. Soinila, S., Mpitsos, G.J., Soinila, J. J. Histochem. Cytochem. (1992) [Pubmed]
  6. Production and characterization of a rat monoclonal antibody against leu5 enkephalin. Hérion, P., De Coen, J.L. Mol. Immunol. (1986) [Pubmed]
  7. Evidence for functional delta-opiate receptors in the rat intestine. Hancock, D.L., Coupar, I.M. J. Pharm. Pharmacol. (1994) [Pubmed]
  8. The opioid activity and receptor selectivity of fluorinated Leu5 enkephalin analogues in vitro and in vivo. Watanabe, J., Tokuyama, S., Takahashi, M., Kaneto, H., Maeda, M., Kawasaki, K., Taguchi, T., Kobayashi, Y., Yamamoto, Y., Shimokawa, K. J. Pharmacobio-dyn. (1991) [Pubmed]
  9. beta-Endorphin: synthesis and analgesic activity of several analogs modified in positions 2 and 5. Yamashiro, D., Li, C.H., Tseng, L.F., Loh, H.H. Int. J. Pept. Protein Res. (1978) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities