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Lrrk2  -  leucine-rich repeat kinase 2

Mus musculus

Synonyms: 4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, ...
 
 
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Disease relevance of Lrrk2

 

High impact information on Lrrk2

 

Anatomical context of Lrrk2

  • However, a more comprehensive map of LRRK2 mRNA localization in the central nervous system is still lacking [1].
  • LRRK2, on the other hand, showed strong regional differences in expression levels with highest levels seen in the striatum, cortex and hippocampus [4].
 

Analytical, diagnostic and therapeutic context of Lrrk2

References

  1. LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain. Simón-Sánchez, J., Herranz-Pérez, V., Olucha-Bordonau, F., Pérez-Tur, J. Eur. J. Neurosci. (2006) [Pubmed]
  2. Biochemical and pathological characterization of Lrrk2. Giasson, B.I., Covy, J.P., Bonini, N.M., Hurtig, H.I., Farrer, M.J., Trojanowski, J.Q., Van Deerlin, V.M. Ann. Neurol. (2006) [Pubmed]
  3. Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain. Higashi, S., Moore, D.J., Colebrooke, R.E., Biskup, S., Dawson, V.L., Arai, H., Dawson, T.M., Emson, P.C. J. Neurochem. (2007) [Pubmed]
  4. Distribution of PINK1 and LRRK2 in rat and mouse brain. Taymans, J.M., Van den Haute, C., Baekelandt, V. J. Neurochem. (2006) [Pubmed]
 
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