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Gene Review

SPAG1  -  sperm associated antigen 1

Homo sapiens

Synonyms: CILD28, CT140, FLJ32920, HSD-3.8, Infertility-related sperm protein Spag-1, ...
 
 
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Disease relevance of SPAG1

  • A 0.7 kb fragment (HSD-0.7) containing three immunological epitopes of HSD-3.8 cDNA was prepared and expressed in E. coli [1].
  • Combined with the finding of its early expression in PDAC development, our data suggest that SPAG1 could contribute to the early spread and poor prognosis of pancreatic adenocarcinoma [2].
 

High impact information on SPAG1

 

Analytical, diagnostic and therapeutic context of SPAG1

  • The de novo biosynthesis of antibody in JP tissue, reactive with A.a. Y4, was demonstrated with Staph Protein A isolated 14C-labeled IgG (SPAG) and the use of a dot-immunobinding assay and autoradiography [4].
  • An exhaust flow rate in the range from 1.0 Lpm below to 1.0 Lpm above inlet flow rate from the small particle aerosol generator (SPAG nebulizer) reduced the leak rate to an average of less than 1%.(ABSTRACT TRUNCATED AT 250 WORDS)[5]

References

  1. A sperm component, HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases (ERK). Liu, N., Qiao, Y., Cai, C., Lin, W., Zhang, J., Miao, S., Zong, S., Koide, S.S., Wang, L. Front. Biosci. (2006) [Pubmed]
  2. Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells. Neesse, A., Gangeswaran, R., Luettges, J., Feakins, R., Weeks, M.E., Lemoine, N.R., Crnogorac-Jurcevic, T. Oncogene (2007) [Pubmed]
  3. Automated reading of red cell antibody identification tests by a solid phase antiglobulin technique. Moore, H.H. Transfusion (1984) [Pubmed]
  4. The gingival immune response to Actinobacillus actinomycetemcomitans in juvenile periodontitis. Hall, E.R., Falkler, W.A., Martin, S.A., Suzuki, J.B. J. Periodontol. (1991) [Pubmed]
  5. A local exhaust ventilation system to reduce airborne ribavirin concentrations. Matlock, D., Buchan, R.M., Tillery, M. American Industrial Hygiene Association journal. (1991) [Pubmed]
 
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