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Gene Review:

Smarcd3 - SWI/SNF related, matrix associated, actin...

Mus musculus

Synonyms: 1500001J14Rik, 2210409C08Rik, 60 kDa BRG-1/Brm-associated factor subunit C, BAF60C, BRG1-associated factor 60C, ...

Lickert, H. et al., Takeuchi, J.K. et al., Takasato, M. et al.

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Disease relevance of Smarcd3

An intermediate reduction in Smarcd3 expression leads to defects in outflow tract remodelling reminiscent of human congenital heart defects [1].

High impact information on Smarcd3

In mice and zebrafish we show that Baf60c, a subunit of the Swi/Snf-like BAF chromatin remodeling complex, is essential for establishment of LR asymmetry [2].
We also found groups of genes including SSB-4, Smarcd3, micro-Crystallin, TRB-2, which are not known to be expressed in the metanephric mesenchyme [3].
Smarcd3 silencing by RNA interference in mouse embryos derived from embryonic stem cells causes defects in heart morphogenesis that reflect impaired expansion of the anterior/secondary heart field, and also results in abnormal cardiac and skeletal muscle differentiation [1].
Here we show that Smarcd3, encoding Baf60c, a subunit of the BAF complexes, is expressed specifically in the heart and somites in the early mouse embryo [1].

References

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Lickert, H., Takeuchi, J.K., Von Both, I., Walls, J.R., McAuliffe, F., Adamson, S.L., Henkelman, R.M., Wrana, J.L., Rossant, J., Bruneau, B.G. Nature (2004) [Pubmed]
Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Takeuchi, J.K., Lickert, H., Bisgrove, B.W., Sun, X., Yamamoto, M., Chawengsaksophak, K., Hamada, H., Yost, H.J., Rossant, J., Bruneau, B.G. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato, M., Osafune, K., Matsumoto, Y., Kataoka, Y., Yoshida, N., Meguro, H., Aburatani, H., Asashima, M., Nishinakamura, R. Mech. Dev. (2004) [Pubmed]

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SMARCD3	Bos taurus
SMARCD3	Canis lupus familiaris
smarcd3b	Danio rerio
SMARCD3	Gallus gallus
SMARCD3	Homo sapiens
SMARCD3	Macaca mulatta
SMARCD3	Pan troglodytes
Smarcd3	Rattus norvegicus
ssr3	Schizosaccharomyces pombe 972h-

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