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Gene Review

Rps6ka6  -  ribosomal protein S6 kinase polypeptide 6

Mus musculus

Synonyms: 2610524K04Rik, RSK4, Ribosomal protein S6 kinase alpha-6, S6K-alpha-6
 
 
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High impact information on Rps6ka6

  • Further examination of Rsk4 expression in the extraembryonic tissues demonstrates that its expression is inversely correlated with the presence of activated ERK 1/2 [1].
  • We demonstrate that Rsk4 inhibits the transcriptional activation of specific targets of RTK signaling as well as the activation of ERK [1].
  • Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling [1].
  • Constitutive activation appeared to result from constitutive phosphorylation of Ser232, Ser372, and Ser389, and the low basal ERK activity in serum-starved cells appeared to be sufficient for induction of approximately 50% of the constitutive RSK4 activity [2].
  • Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis [3].

References

  1. Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling. Myers, A.P., Corson, L.B., Rossant, J., Baker, J.C. Mol. Cell. Biol. (2004) [Pubmed]
  2. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. Dümmler, B.A., Hauge, C., Silber, J., Yntema, H.G., Kruse, L.S., Kofoed, B., Hemmings, B.A., Alessi, D.R., Frödin, M. J. Biol. Chem. (2005) [Pubmed]
  3. Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis. Kohn, M., Hameister, H., Vogel, M., Kehrer-Sawatzki, H. Gene Expr. Patterns (2003) [Pubmed]
 
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