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Gene Review:

Tomm34 - translocase of outer mitochondrial...

Mus musculus

Synonyms: 2610100K07Rik, Mitochondrial import receptor subunit TOM34, TOM34, Translocase of outer membrane 34 kDa subunit

Terada, K. et al., Joseph, A.M. et al.

Terada, Ueno, Yomogida, Imai, Kiyonari, Takeda, Yano, Abe, Aizawa, Mori,

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High impact information on Tomm34

In contrast, in MELAS cells mtHSP70 was elevated by 70%, whereas Tom20 and Tom34 protein levels were increased by 45% and 112% relative to control values [1].
In vitro-preprotein import into isolated mitochondria showed no apparent difference between Tom34(-/-) and wild-type mice [2].
Expression of Tom34 splicing isoforms in mouse testis and knockout of Tom34 in mice [2].
These results indicate that Tom34 is dispensable for mouse growth and development under optimal conditions [2].
We analyzed the genomic sequence of the mouse Tom34 gene and found it has two alternative initial exons [2].

Biological context of Tomm34

The Tom34(-/-) mice were viable and grew normally and had a normal Mendelian inheritance pattern [2].

Anatomical context of Tomm34

Tom34 mRNA with exon 1a (Tom34a) is expressed ubiquitously, while that with exon 1b (Tom34b) is expressed only in mature testicular germ cells [2].
The 34-kDa translocase of the outer mitochondrial membrane (Tom34) is a putative mammalian-specific factor involved in protein import into mitochondria [2].

References

Compensatory responses of protein import and transcription factor expression in mitochondrial DNA defects. Joseph, A.M., Rungi, A.A., Robinson, B.H., Hood, D.A. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
Expression of Tom34 splicing isoforms in mouse testis and knockout of Tom34 in mice. Terada, K., Ueno, S., Yomogida, K., Imai, T., Kiyonari, H., Takeda, N., Yano, M., Abe, S., Aizawa, S., Mori, M. J. Biochem. (2003) [Pubmed]

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