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Pdcl  -  phosducin-like

Mus musculus

Synonyms: 1200011E13Rik, AW108059, PHLP, PhLP1, Phosducin-like protein
 
 
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High impact information on Pdcl

  • We identified a new member of the phosducin-like (PhLP) protein family that is predominantly, if not exclusively, expressed in male and female germ cells [1].
  • The predicted amino acid sequence shows extensive similarities not only with the known mammalian PhLP proteins but also with the yeast phosducin-like protein Plp2, required for the production and growth of haploid cells [1].
  • This paper reports the presence of N-glycosylated phosducin-like protein long (PhLP(L)) in all structures of mouse CNS, mainly in synaptic plasma membranes and associated with G beta subunits and 14-3-3 proteins [2].
  • Phosducin is found exclusively in photoreceptor cells, including the synaptic and nuclear layers, while phosducin-like protein is found throughout the inner retinal layers, most abundantly in the bipolar cells of the inner nuclear layer [3].
  • The sensitivity of phosducin-like protein to phosphorylation was probed using in vitro protein kinase reactions [3].
 

Biological context of Pdcl

References

  1. A novel germ line-specific gene of the phosducin-like protein (PhLP) family. A meiotic function conserved from yeast to mice. Lopez, P., Yaman, R., Lopez-Fernandez, L.A., Vidal, F., Puel, D., Clertant, P., Cuzin, F., Rassoulzadegan, M. J. Biol. Chem. (2003) [Pubmed]
  2. Glycosylated phosducin-like protein long regulates opioid receptor function in mouse brain. Garzón, J., Rodríguez-Díaz, M., López-Fando, A., García-España, A., Sánchez-Blázquez, P. Neuropharmacology (2002) [Pubmed]
  3. The immunolocalization and divergent roles of phosducin and phosducin-like protein in the retina. Thulin, C.D., Howes, K., Driscoll, C.D., Savage, J.R., Rand, T.A., Baehr, W., Willardson, B.M. Mol. Vis. (1999) [Pubmed]
 
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