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Gene Review:

Rnf41 - ring finger protein 41

Mus musculus

Synonyms: 2210404G21Rik, 4930511A05Rik, 4933415P08Rik, D10Ertd722e, E3 ubiquitin-protein ligase NRDP1, ...

Abdullah, J.M. et al.

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Disease relevance of Rnf41

Evolutionary conservation and differential expression in fetal and adult HSC and progenitors suggest that the FLRF gene could play an important role in HSC/progenitor cell lineage commitment and differentiation and could be involved in the etiology of hematological malignancies [1].
The human FLRF gene that spans a region of at least 12 kb and consists of eight exons was localized to chromosome 12q13, a region with frequent chromosome aberrations associated with multiple cases of acute myeloid leukemia and non-Hodgkin's lymphoma [1].

High impact information on Rnf41

In adult mice FLRF is not transcribed in a highly enriched population of bone marrow HSC (Rh-123lowSca-1+c-kit+Lin- cells) [1].
Through differential screening of mouse hematopoietic stem cell (HSC) and progenitor subtracted cDNA libraries we have identified a HSC-specific transcript that represents a novel RING finger gene, named FLRF (fetal liver ring finger) [1].
During embryonic hematopoiesis FLRF is abundantly transcribed in mouse fetal liver HSC (Sca-1+c-kit+AA4.1+Lin- cells), but is not expressed in progenitors (AA4.1-) [1].

References

FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors. Abdullah, J.M., Li, X., Nachtman, R.G., Jurecic, R. Blood Cells Mol. Dis. (2001) [Pubmed]

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