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Gene Review:

Reg4 - regenerating islet-derived family, member 4

Mus musculus

Synonyms: 2010002L15Rik, GISP, REG-4, RELP, Regenerating islet-derived protein 4

Kämäräinen, M. et al.

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Disease relevance of Reg4

An up-regulated expression of RELP was seen in epithelial cells of inflammatory mucosa in ulcerative colitis and Crohn's disease, in regenerating epithelial borders of gastric ulcers, and in metaplastic epithelium in the antrum and the esophagus [1].

High impact information on Reg4

Our findings suggest that RELP might be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium [1].
Unlike the reg genes, which form a cluster in chromosome 2, relp maps to chromosome 1p12-13 [1].
The RELP protein is constitutively expressed in epithelial neuroendocrine cells of the small intestine and in parietal cells of the gastric mucosa [1].

References

RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. Kämäräinen, M., Heiskala, K., Knuutila, S., Heiskala, M., Winqvist, O., Andersson, L.C. Am. J. Pathol. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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LOC100485321	Xenopus (Silurana) tropicalis
LOC100485485	Xenopus (Silurana) tropicalis

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