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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tomm20  -  translocase of outer mitochondrial...

Mus musculus

Synonyms: 1810060K07Rik, BB284719, Gm19268, MAS20, MOM19, ...
 
 
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High impact information on Tomm20

  • Upon further entry of the preprotein into the translocation pore, the presequence loses its contact with Tom20/Tom22, but remains in firm association with Tom40 [1].
  • In rho(-) cells, Tom20 and Tim23 protein levels were reduced by 25% and 59%, whereas mtHSP70 was induced by twofold relative to control cells [2].
  • In contrast, in MELAS cells mtHSP70 was elevated by 70%, whereas Tom20 and Tom34 protein levels were increased by 45% and 112% relative to control values [2].
  • Colocalisation studies with TOM-20, a protein also present in the outer mitochondrial membrane, showed that VDAC proteins localised only to peripheral and not to perinuclear mitochondria [3].
 

Other interactions of Tomm20

  • Preproteins bound to the surface-exposed cis site can be cross-linked via their N-terminal presequence to Tom20 and Tom22, demonstrating their direct association with this part of the preprotein [1].

References

  1. Mitochondrial protein import. Tom40 plays a major role in targeting and translocation of preproteins by forming a specific binding site for the presequence. Rapaport, D., Neupert, W., Lill, R. J. Biol. Chem. (1997) [Pubmed]
  2. Compensatory responses of protein import and transcription factor expression in mitochondrial DNA defects. Joseph, A.M., Rungi, A.A., Robinson, B.H., Hood, D.A. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  3. Voltage-dependent anion channel localises to the plasma membrane and peripheral but not perinuclear mitochondria. Bahamonde, M.I., Valverde, M.A. Pflugers Arch. (2003) [Pubmed]
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