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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ebpl  -  emopamil binding protein-like

Mus musculus

Synonyms: 5730442K12Rik, EBRP, Ebrp, Emopamil-binding protein-like, Emopamil-binding-related protein, ...
 
 
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Disease relevance of Ebpl

 

High impact information on Ebpl

  • The Mycobacterium tuberculosis exported repetitive protein (Erp) is a virulence determinant required for growth in cultured macrophages and in vivo [1].
  • A detailed microscopic examination of infected embryos revealed that bacteria lacking Erp were compromised very early in infection, failing to grow and/or survive upon phagocytosis by host macrophages [1].
  • Many Erp proteins serve as receptors for the complement inhibitory factor H molecules of numerous vertebrate hosts, providing one mechanism by which the bacteria potentially evade the innate immune system [2].
 

Analytical, diagnostic and therapeutic context of Ebpl

  • Indirect immunofluorescence analyses (IFA) have demonstrated that Erp expression is temporally regulated throughout the mammal-tick infectious cycle, indicating that Erp proteins perform an important role (or even roles) during mammalian infection [2].

References

  1. Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival. Cosma, C.L., Klein, K., Kim, R., Beery, D., Ramakrishnan, L. Infect. Immun. (2006) [Pubmed]
  2. Borrelia burgdorferi erp genes are expressed at different levels within tissues of chronically infected mammalian hosts. Miller, J.C., Stevenson, B. Int. J. Med. Microbiol. (2006) [Pubmed]
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