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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cdan1  -  congenital dyserythropoietic anemia, type...

Mus musculus

Synonyms: 1500015A01Rik, AI448026, AW492297, CDA-I, CDA1, ...
 
 
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Disease relevance of Cdan1

  • Three anti-toxin A HuMAbs (3H2, CDA1, and 1B11) could all inhibit the enterotoxicity of toxin A in mouse intestinal loops and the in vivo toxicity in a systemic mouse model [1].
 

High impact information on Cdan1

  • The specific mechanisms by which codanin-1 underlies normal erythropoiesis remain to be elucidated [2].
  • A dramatic reduction in lymphocyte and monocyte TNFalpha producing cells, together a clinical remission (CDAI < 150), was shown after the treatments [3].

References

  1. Human Monoclonal Antibodies Directed against Toxins A and B Prevent Clostridium difficile-Induced Mortality in Hamsters. Babcock, G.J., Broering, T.J., Hernandez, H.J., Mandell, R.B., Donahue, K., Boatright, N., Stack, A.M., Lowy, I., Graziano, R., Molrine, D., Ambrosino, D.M., Thomas, W.D. Infect. Immun. (2006) [Pubmed]
  2. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Dgany, O., Avidan, N., Delaunay, J., Krasnov, T., Shalmon, L., Shalev, H., Eidelitz-Markus, T., Kapelushnik, J., Cattan, D., Pariente, A., Tulliez, M., Crétien, A., Schischmanoff, P.O., Iolascon, A., Fibach, E., Koren, A., Rössler, J., Le Merrer, M., Yaniv, I., Zaizov, R., Ben-Asher, E., Olender, T., Lancet, D., Beckmann, J.S., Tamary, H. Am. J. Hum. Genet. (2002) [Pubmed]
  3. A chimeric anti-TNFalpha monoclonal antibody (cA2) in vivo removes TNFalpha-producing cells in Crohn's disease. Urra, J.M., Arteta, M., Gómez-Caturla, A., García-Durán, F. Human antibodies. (2001) [Pubmed]
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