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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Slc30a5  -  solute carrier family 30 (zinc...

Mus musculus

Synonyms: 1810010K08Rik, AF233321, Solute carrier family 30 member 5, ZNT5, ZTL1, ...
 
 
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Disease relevance of Slc30a5

 

High impact information on Slc30a5

  • These results indicate that Znt5 protein plays an important role in maturation of osteoblasts and in maintenance of the cells involved in the cardiac conduction system, partly owing to dysregulated expression of IEGs and HSPs [1].
  • Furthermore, we showed that expression of ZnT5 mRNA was up-regulated by the endoplasmic reticulum stress in various cell lines [2].
  • These results suggest that ZnT-5 plays an important role for transporting zinc into secretory granules in pancreatic beta cells [3].

References

  1. Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Inoue, K., Matsuda, K., Itoh, M., Kawaguchi, H., Tomoike, H., Aoyagi, T., Nagai, R., Hori, M., Nakamura, Y., Tanaka, T. Hum. Mol. Genet. (2002) [Pubmed]
  2. Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells. Ishihara, K., Yamazaki, T., Ishida, Y., Suzuki, T., Oda, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T. J. Biol. Chem. (2006) [Pubmed]
  3. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. Kambe, T., Narita, H., Yamaguchi-Iwai, Y., Hirose, J., Amano, T., Sugiura, N., Sasaki, R., Mori, K., Iwanaga, T., Nagao, M. J. Biol. Chem. (2002) [Pubmed]
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