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Gene Review:

MAMU-DRB1 - MHC class II antigen

Macaca mulatta

Leonard, A.A. et al., de Groot, N. et al., Evans, D.T. et al., Evans, D.T. et al., Knapp, L.A. et al., et al.

de Groot, Doxiadis, De Groot, Otting, Heijmans, Rouweler, Bontrop,

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Disease relevance of MAMU-DRB

Since all five offspring were identical at their Mamu-DRB loci, MHC class II differences are unlikely to account for their patterns of disease progression [1].

High impact information on MAMU-DRB

At least 30 Mamu-DRB region configurations, displaying polymorphism with regard to number and combination of DRB loci present per haplotype, have been characterized [2].
The highly variable second exon of Mamu-DRB alleles was amplified using generic DRB primers and alleles were separated by DGGE [3].

Chemical compound and disease context of MAMU-DRB

Since all four of these macaques were Mamu-DRB-identical, we were able to exclude the MHC class II DRB loci as determinant of disease progression [4].

Analytical, diagnostic and therapeutic context of MAMU-DRB

This effect seems to be negated by a mismatched MHC class II antigen in the blood transfusion donor which is also present in the organ donor -- a so-called repeated mismatch [5].
This analysis demonstrated that most of the amplicons were identical to Mamu-DRB alleles that our PCR primers were to amplify [6].

References

Definition of five new simian immunodeficiency virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression. Evans, D.T., Jing, P., Allen, T.M., O'Connor, D.H., Horton, H., Venham, J.E., Piekarczyk, M., Dzuris, J., Dykhuzen, M., Mitchen, J., Rudersdorf, R.A., Pauza, C.D., Sette, A., Bontrop, R.E., DeMars, R., Watkins, D.I. J. Virol. (2000) [Pubmed]
Genetic makeup of the DR region in rhesus macaques: gene content, transcripts, and pseudogenes. de Groot, N., Doxiadis, G.G., De Groot, N.G., Otting, N., Heijmans, C., Rouweler, A.J., Bontrop, R.E. J. Immunol. (2004) [Pubmed]
Identification of new mamu-DRB alleles using DGGE and direct sequencing. Knapp, L.A., Cadavid, L.F., Eberle, M.E., Knechtle, S.J., Bontrop, R.E., Watkins, D.I. Immunogenetics (1997) [Pubmed]
Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV. Evans, D.T., Knapp, L.A., Jing, P., Mitchen, J.L., Dykhuizen, M., Montefiori, D.C., Pauza, C.D., Watkins, D.I. Immunol. Lett. (1999) [Pubmed]
Complete withdrawal of immunosuppression in allograft recipients. A study in rhesus monkeys. Leonard, A.A., Jonker, M., Lagaaij, E.L. Transplantation (1996) [Pubmed]
Identification of DRB alleles in rhesus monkeys using polymerase chain reaction-sequence-specific primers (PCR-SSP) amplification. Lobashevsky, A., Smith, J.P., Kasten-Jolly, J., Horton, H., Knapp, L., Bontrop, R.E., Watkins, D., Thomas, J. Tissue Antigens (1999) [Pubmed]

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