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Gene Review

Pacrg  -  PARK2 co-regulated

Mus musculus

Synonyms: 1700008H23Rik, Hypertension-related protein 1-like protein, PARK2 coregulated gene protein, Parkin coregulated gene protein homolog
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Disease relevance of Pacrg


High impact information on Pacrg

  • In addition, the expression pattern of Pacrg during spermiogenesis suggests that it plays a role in sperm differentiation [1].
  • We show that Pacrg is highly expressed in the testes in both mice and humans [1].
  • Immunolocalization experiments on isolated spermatozoa show that the Pacrg protein is present in mature sperm [1].
  • The quaking mutation is a deletion of approximately 1.17 Mb of mouse chromosome 17, resulting in the deletion of the entire promoter and first five coding exons of PRKN In addition, the recently described Parkin Co-Regulated Gene (PACRG) is completely deleted [2].

Associations of Pacrg with chemical compounds

  • It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG) [2].


  1. Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant. Lorenzetti, D., Bishop, C.E., Justice, M.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG). Lockhart, P.J., O'Farrell, C.A., Farrer, M.J. Mov. Disord. (2004) [Pubmed]
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