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Antxr1  -  anthrax toxin receptor 1

Mus musculus

Synonyms: 2310008J16Rik, 2810405N18Rik, Anthrax toxin receptor 1, Antrx1, Atr, ...
 
 
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Disease relevance of Antxr1

  • ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection [1].
  • To examine the role of MPT pores, mice were administered atractyloside (Atr; 25 mg/kg i.v.), which induces adenine nucleotide translocase-dependent MPT, 20 min before ischemia [2].
 

High impact information on Antxr1

  • However, selective expression of TEM8 in endothelial cells contradicts the presumably ubiquitous expression of the receptor [1].
  • Furthermore, immunostaining of skin biopsies revealed that ATR/TEM8 is highly expressed in the keratinocytes of the epidermis [1].
  • In fact, we show that ATR/TEM8 is highly expressed in the respiratory epithelium of the bronchi of the lung and is particularly abundant in the ciliated epithelial cells coating the bronchi [1].
  • TEM8 is selectively upregulated in endothelial cells during blood vessel formation and tumorigenesis [1].
  • In accordance with the effects on infarct size, administration of Atr to the mice significantly abrogated DETA/NO-induced protection against Ca(2+)-induced mitochondrial swelling [2].
 

Biological context of Antxr1

 

Anatomical context of Antxr1

  • This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, which represent the primary location for bacterial invasion [1].
  • Distribution of Atr protein in primary spermatocytes of a mouse chromosomal mutant: a comparison of preparation techniques [3].

References

  1. ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection. Bonuccelli, G., Sotgia, F., Frank, P.G., Williams, T.M., de Almeida, C.J., Tanowitz, H.B., Scherer, P.E., Hotchkiss, K.A., Terman, B.I., Rollman, B., Alileche, A., Brojatsch, J., Lisanti, M.P. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  2. Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. Wang, G., Liem, D.A., Vondriska, T.M., Honda, H.M., Korge, P., Pantaleon, D.M., Qiao, X., Wang, Y., Weiss, J.N., Ping, P. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  3. Distribution of Atr protein in primary spermatocytes of a mouse chromosomal mutant: a comparison of preparation techniques. Baart, E.B., de Rooij, D.G., Keegan, K.S., de Boer, P. Chromosoma (2000) [Pubmed]
 
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