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Gene Review:

TCTE1 - t-complex-associated-testis-expressed 1

Homo sapiens

This record was replaced with 202500.

Kwiatkowski, T.J. et al., Watanabe, T.K. et al., Chatkupt, S. et al., Zoghbi, H.Y. et al., Mundlos, S. et al.

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Disease relevance of TCTE1

Members of a 5-generation family with sacral defect and anterior meningocele (SDAM) were typed with polymorphic markers (dinucleotide repeats D6S89, D6S105, D6S109, and TCTE1) linked to HLA [1].

High impact information on TCTE1

A maximum pairwise lod score of 4.54 at a recombination frequency of .100 was obtained for SCA1 and TCTE1 in the HSCA1 kindred [2].
Linkage was established between CCD and four loci (D6S426, D6S451, D6S459, TCTE1) that span a region of 10 cM on chromosome 6p [3].
Linkage mapping and fluorescence in situ hybridization of TCTE1 on human chromosome 6p: analysis of dinucleotide polymorphisms on native gels [4].
Highly informative dinucleotide repeat polymorphisms were identified at the T-complex-associated-testes-expressed-1 (TCTE1) locus on human chromosome 6p [4].
A sequence tagged site (STS) was established, and three yeast artificial chromosome (YAC) clones were identified for the TCTE1 locus [4].

Biological context of TCTE1

From a human fetal-brain cDNA library we isolated a putative human homologue of the murine Tcte1 gene [5].

Other interactions of TCTE1

Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q [5].

Analytical, diagnostic and therapeutic context of TCTE1

Two-color fluorescence in situ hybridization places TCTE1 proximal to CRIL171 (D6S19) [4].

References

Linkage analysis of a candidate locus (HLA) in autosomal dominant sacral defect with anterior meningocele. Chatkupt, S., Speer, M.C., Ding, Y., Thomas, M., Stenroos, E.S., Dermody, J.J., Koenigsberger, M.R., Ott, J., Johnson, W.G. Am. J. Med. Genet. (1994) [Pubmed]
The gene for autosomal dominant spinocerebellar ataxia (SCA1) maps telomeric to the HLA complex and is closely linked to the D6S89 locus in three large kindreds. Zoghbi, H.Y., Jodice, C., Sandkuijl, L.A., Kwiatkowski, T.J., McCall, A.E., Huntoon, S.A., Lulli, P., Spadaro, M., Litt, M., Cann, H.M. Am. J. Hum. Genet. (1991) [Pubmed]
Genetic mapping of cleidocranial dysplasia and evidence of a microdeletion in one family. Mundlos, S., Mulliken, J.B., Abramson, D.L., Warman, M.L., Knoll, J.H., Olsen, B.R. Hum. Mol. Genet. (1995) [Pubmed]
Linkage mapping and fluorescence in situ hybridization of TCTE1 on human chromosome 6p: analysis of dinucleotide polymorphisms on native gels. Kwiatkowski, T.J., Beaudet, A.L., Trask, B.J., Zoghbi, H.Y. Genomics (1991) [Pubmed]
Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. Watanabe, T.K., Fujiwara, T., Shimizu, F., Okuno, S., Suzuki, M., Takahashi, E., Nakamura, Y., Hirai, Y. Cytogenet. Cell Genet. (1996) [Pubmed]

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