Gene Review:
Mutyh - mutY homolog (E. coli)
Mus musculus
Synonyms:
5730495A01Rik, A/G-specific adenine DNA glycosylase, MutY homolog, Mutyha, Mutyhalpha, ...
- Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Xie, Y., Yang, H., Cunanan, C., Okamoto, K., Shibata, D., Pan, J., Barnes, D.E., Lindahl, T., McIlhatton, M., Fishel, R., Miller, J.H. Cancer Res. (2004)
- DNA damage recognition and repair by the murine MutY homologue. Pope, M.A., David, S.S. DNA Repair (Amst.) (2005)
- MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis. Sakamoto, K., Tominaga, Y., Yamauchi, K., Nakatsu, Y., Sakumi, K., Yoshiyama, K., Egashira, A., Kura, S., Yao, T., Tsuneyoshi, M., Maki, H., Nakabeppu, Y., Tsuzuki, T. Cancer Res. (2007)
- Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases. Russo, M.T., De Luca, G., Degan, P., Parlanti, E., Dogliotti, E., Barnes, D.E., Lindahl, T., Yang, H., Miller, J.H., Bignami, M. Cancer Res. (2004)
- Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice. Sieber, O.M., Howarth, K.M., Thirlwell, C., Rowan, A., Mandir, N., Goodlad, R.A., Gilkar, A., Spencer-Dene, B., Stamp, G., Johnson, V., Silver, A., Yang, H., Miller, J.H., Ilyas, M., Tomlinson, I.P. Cancer Res. (2004)
- The physical map of Mus musculus chromosome 11 reveals evolutionary relationships with different syntenic groups of genes in Homo sapiens. Münke, M., Francke, U. J. Mol. Evol. (1987)
- Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts. Ichinoe, A., Behmanesh, M., Tominaga, Y., Ushijima, Y., Hirano, S., Sakai, Y., Tsuchimoto, D., Sakumi, K., Wake, N., Nakabeppu, Y. Nucleic Acids Res. (2004)
- Functional cooperation of Ogg1 and Mutyh in preventing G: C-->T: a transversions in mice. Isogawa, A. Fukuoka Igaku Zasshi (2004)
- MutY and MutY homologs (MYH) in genome maintenance. Lu, A.L., Bai, H., Shi, G., Chang, D.Y. Front. Biosci. (2006)
- MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain. Tominaga, Y., Ushijima, Y., Tsuchimoto, D., Mishima, M., Shirakawa, M., Hirano, S., Sakumi, K., Nakabeppu, Y. Nucleic Acids Res. (2004)
- A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA. Ushijima, Y., Tominaga, Y., Miura, T., Tsuchimoto, D., Sakumi, K., Nakabeppu, Y. Nucleic Acids Res. (2005)
- Insight into the functional consequences of hMYH variants associated with colorectal cancer: distinct differences in the adenine glycosylase activity and the response to AP endonucleases of Y150C and G365D murine MYH. Pope, M.A., Chmiel, N.H., David, S.S. DNA Repair (Amst.) (2005)