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Gene Review

Prdm16  -  PR domain containing 16

Mus musculus

Synonyms: 5730557K01Rik, Kiaa1675, MDS1/EVI1-like gene 1, Mel1, PR domain zinc finger protein 16, ...
 
 
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Disease relevance of Prdm16

  • Human ACHN (renal), NIH-OVCAR-3 (ovarian), LNCaP (prostate), and SK-Mel-1 (melanoma) tumor cells were inoculated intradermally into the flanks of nude mice [1].
 

High impact information on Prdm16

  • One of them, melanoblast/cyte early marker (MelEM) monoclonal antibody (Mab) detects melanoblasts as soon as they have reached the subectodermal mesenchyme, while the two others, Mel1 and Mel2 Mabs, detect antigens present in melanosomes and promelanosomes later in the differentiation process [2].
  • Three mAbs of IgG1 isotype were selected: Mel-1, Mel-2 and Mel-3 which recognised the immunogen by ELISA and stained several melanoma cell lines positive in immunofluorescence [3].
  • Opioid antagonist properties of the highly delta-receptor-selective BOC-Tyr-Pro-Gly-Phe-Leu-Thr (OtBu) peptide and of its Phe1 and Mel1 analogues [4].

References

  1. IFN-alpha2b and thalidomide synergistically inhibit tumor-induced angiogenesis. Bauer, J.A., Morrison, B.H., Grane, R.W., Jacobs, B.S., Borden, E.C., Lindner, D.J. J. Interferon Cytokine Res. (2003) [Pubmed]
  2. Novel markers of melanocyte differentiation in the avian embryo. Nataf, V., Mercier, P., Ziller, C., Le Douarin, N.M. Exp. Cell Res. (1993) [Pubmed]
  3. Cell-cell adherence as a selection method for the generation of anti-melanoma monoclonal antibodies. Barral, A.M., Fernández, A., Faxas, M.E., Pérez, X., García, C.A., Rosén, A. J. Immunol. Methods (1997) [Pubmed]
  4. Opioid antagonist properties of the highly delta-receptor-selective BOC-Tyr-Pro-Gly-Phe-Leu-Thr (OtBu) peptide and of its Phe1 and Mel1 analogues. Rónai, A.Z., Magyar, A., Orosz, G., Borsodi, A., Benyhe, S., Tóth, G., Makó, E., Kátay, E., Babka, E., Medzihradszky, K. Archives internationales de pharmacodynamie et de thérapie. (1995) [Pubmed]
 
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