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Gene Review

Atoh8  -  atonal homolog 8 (Drosophila)

Mus musculus

Synonyms: 4933425C05Rik, Ath6, Hath6, Helix-loop-helix protein mATH-6, Math6, ...
 
 
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Disease relevance of Atoh8

  • Mis-expression of Math6 with retrovirus in the developing retina induced neurogenesis, while inhibiting gliogenesis, without affecting cell proliferation and death [1].
  • We identify here Math6 as a podocyte-expressed bHLH protein that was down-regulated in human immunodeficiency virus-associated nephropathy (HIVAN); a collapsing glomerulopathy characterized by podocyte dedifferentiation [2].
 

High impact information on Atoh8

  • In adult kidney, Math6 expression was restricted to podocytes [2].
  • Early in metanephric development, Math6 was expressed in metanephric mesenchyme but not ureteric bud-derived cells, with overall Math6 expression most abundant in the nephrogenic zone, including developing glomeruli [2].
  • Math6 is a tissue-restricted member of the Atonal family of basic helix-loop-helix (bHLH) transcription factors and has been implicated in specification and differentiation of cell lineages in the brain [2].
  • Math6 is initially expressed by neural precursor cells in the ventricular zone, but later by subsets of differentiating and mature neurones such as hippocampal neurones and cerebellar Purkinje cells [1].
  • Structural analysis of the Math6 gene demonstrated that the coding region is divided into three exons, whereas that of other atonal homologues is present in a single exon, indicating that the genomic structure of Math6 is unique among the atonal homologues [1].

References

  1. Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation. Inoue, C., Bae, S.K., Takatsuka, K., Inoue, T., Bessho, Y., Kageyama, R. Genes Cells (2001) [Pubmed]
  2. Math6 expression during kidney development and altered expression in a mouse model of glomerulosclerosis. Ross, M.D., Martinka, S., Mukherjee, A., Sedor, J.R., Vinson, C., Bruggeman, L.A. Dev. Dyn. (2006) [Pubmed]
 
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