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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Clmp  -  CXADR-like membrane protein

Mus musculus

Synonyms: 9030425E11Rik, ACAM, ASP5, AW557819, Acam, ...
 
 
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High impact information on 9030425E11Rik

  • Immunostaining with ASP5p showed that parkin is principally located in the cytoplasm of neurons that are widely distributed in the rat brain [1].
  • We show here that this Cam-related gene is specifically expressed in the germ-line of the testis, leading to the name Androcam (Acam) [2].
  • Late in spermiogenesis, some Acam staining overlaps the periphery of the investment cones, actin-containing structures hypothesized to support the motor function for cytoplasmic stripping of the tail [2].
  • FLJ22415 is the human ortholog of mouse Asp5 and rat OL-16 specifically expressed in adipose tissue [3].
 

Anatomical context of 9030425E11Rik

  • Proteins more related to Acam than Cam are present in the testes of other Drosophila species and a mammalian species, the mouse [2].
 

Analytical, diagnostic and therapeutic context of 9030425E11Rik

  • Western blotting revealed that ASP5p recognizes a single 52-kDa band, which corresponds to the molecular mass of the parkin protein [1].
  • Acam cannot be detected in mature sperm by immunolocalization, but immunoblotting established that Acam is present in sperm stored in mated females, suggesting epitope masking during final maturation [2].
  • Two analogues of alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2), Ac-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH4-10NH2 and Ac-[Nle4, Asp5, D-Phe7, Lys10] alpha-MSH4-10-NH2, were synthesized, and the melanotropic activities of the peptides were compared in several bioassays [4].

References

  1. Cloning of rat parkin cDNA and distribution of parkin in rat brain. Gu, W.J., Abbas, N., Lagunes, M.Z., Parent, A., Pradier, L., Bohme, G.A., Agid, Y., Hirsch, E.C., Raisman-Vozari, R., Brice, A. J. Neurochem. (2000) [Pubmed]
  2. Androcam, a Drosophila calmodulin-related protein, is expressed specifically in the testis and decorates loop kl-3 of the Y chromosome. Lu, A.Q., Beckingham, K. Mech. Dev. (2000) [Pubmed]
  3. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
  4. Linear and cyclic alpha-melanotropin [4-10]-fragment analogues that exhibit superpotency and residual activity. Hadley, M.E., Marwan, M.M., al-Obeidi, F., Hruby, V.J., Castrucci, A.M. Pigment Cell Res. (1989) [Pubmed]
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