The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Bmper  -  BMP-binding endothelial regulator

Mus musculus

Synonyms: 3110056H04Rik, BMP-binding endothelial regulator protein, Bone morphogenetic protein-binding endothelial cell precursor-derived regulator, CV-2, Crim3, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Bmper

  • NEPHGE 57 was dramatically increased in C4 and CV2 tissues and cultured cells and may be related to expression of squamous metaplasia and keratinization which are characteristic of these lesions [1].
  • The preneoplastic lesions were hyperplastic alveolar nodules (HAN) derived originally from mice treated by hormonal stimulation (D2), exposed to a chemical carcinogen (C4), or spontaneously expressing mouse mammary tumor virus (CV2) and maintained by serial transplantation [1].
  • The CV2 flora included fewer gram-positive anaerobic cocci as well as higher proportions of yeasts, staphylococci and enterobacteriaceae compared with the SPF and CV1 flora [2].
 

High impact information on Bmper

  • BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation [3].
  • In Xenopus embryos, ventral injection of BMPER mRNA results in axis duplication and downregulation of the expression of Xvent-1 (downstream target of Smad signaling) [3].
  • Moreover, the defects in the vertebral column and eyes of the Cv2(-/-) mouse are substantially enhanced by deleting one copy of the Bmp4 gene, suggesting a pro-Bmp role of Cv2 in the development of these organs [4].
  • This kidney hypoplasia is synergistically enhanced by the additional deletion of Kcp (Crim2) which encodes a pro-Bmp protein structurally related to Cv2 [4].
  • Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis [4].
 

Biological context of Bmper

  • The mutant phenotype in Drosophila suggests that CV-2 is required for the differentiation of crossvein structures in the wing which require high Dpp levels [5].
  • The CV1 and CV2 group transgenic mice were transferred with the intestinal flora from two different mouse facilities housed under conventional conditions, and the SPF group transgenic mice were kept under specific pathogen free conditions in our facility [2].
 

Anatomical context of Bmper

  • Cartilage differentiation by Bmp4 treatment is reduced in cultured Cv2(-/-) fibroblasts [4].
  • We termed this protein BMPER (bone morphogenetic protein [BMP]-binding endothelial cell precursor-derived regulator) [3].
  • Likewise, a Mr 46,000 polypeptide (IEF 46), which has been tentatively identified previously as a keratin, was absent in normal epithelium but present in all abnormal tissues except the C4 and CV2 HAN [1].
  • The numbers of tissue neutrophils were higher in the CV2 group than in the SPF and CV1 groups at 18 months [2].
  • In contrast, amyloid was deposited in the esophagus and small intestine of two of the three CV2 mice at 18 months [2].
 

Associations of Bmper with chemical compounds

  • In addition, the Cv2(-/-) mutant exhibits substantial defects in Bmp-dependent processes of internal organ formation, such as nephron generation in the kidney [4].
  • A Mr 56,000 polypeptide (NEPHGE 56) was detected only in C4 HAN and C4 and CV2 tumor cells [1].

References

  1. Heterogeneity of keratin expression in mouse mammary hyperplastic alveolar nodules and adenocarcinomas. Asch, H.L., Asch, B.B. Cancer Res. (1985) [Pubmed]
  2. Effect of the intestinal flora on amyloid deposition in a transgenic mouse model of familial amyloidotic polyneuropathy. Noguchi, H., Ohta, M., Wakasugi, S., Noguchi, K., Nakamura, N., Nakamura, O., Miyakawa, K., Takeya, M., Suzuki, M., Nakagata, N., Urano, T., Ono, T., Yamamura, K. Exp. Anim. (2002) [Pubmed]
  3. BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Moser, M., Binder, O., Wu, Y., Aitsebaomo, J., Ren, R., Bode, C., Bautch, V.L., Conlon, F.L., Patterson, C. Mol. Cell. Biol. (2003) [Pubmed]
  4. Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Ikeya, M., Kawada, M., Kiyonari, H., Sasai, N., Nakao, K., Furuta, Y., Sasai, Y. Development (2006) [Pubmed]
  5. Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. Coffinier, C., Ketpura, N., Tran, U., Geissert, D., De Robertis, E.M. Mech. Dev. (2002) [Pubmed]
 
WikiGenes - Universities