The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

VTNR  -  vitronectin receptor

Homo sapiens

This record was replaced with 3685.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of VTNR


High impact information on VTNR


Chemical compound and disease context of VTNR


Biological context of VTNR


Anatomical context of VTNR


Associations of VTNR with chemical compounds

  • Acute cellular rejection following human heart transplantation is associated with increased expression of vitronectin receptor (integrin alphavbeta3) [14].
  • This work shows that in three different lesional tissues, bone, skin, and lymph node, the MGCs expressed the characteristic osteoclast markers, tartrate-resistant acid phosphatase and vitronectin receptor, as well as the enzymes cathepsin K and matrix metalloproteinase-9 [22].
  • This beta subunit and the glycoprotein IIIa beta subunit (beta 3) were both found complexed with VNR alpha on MG-63 cells and in at least two other human cell types we examined [4].
  • On vitronectin-coated surfaces, or substrata derivatized with a tridecapeptide containing the cell attachment sequence Arg-Gly-Asp, both FNR and VNR became concentrated at focal contacts [23].
  • Finally, NH2 terminal amino acid sequencing showed that the amino-terminus of the monkey alpha chain was identical in the 12 assigned residues to that of human VNR alpha chain [3].

Physical interactions of VTNR


Enzymatic interactions of VTNR


Regulatory relationships of VTNR


Other interactions of VTNR


Analytical, diagnostic and therapeutic context of VTNR


  1. Coordinated expression of the vitronectin receptor and the urokinase-type plasminogen activator receptor in metastatic melanoma cells. Nip, J., Rabbani, S.A., Shibata, H.R., Brodt, P. J. Clin. Invest. (1995) [Pubmed]
  2. Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. Gladson, C.L., Cheresh, D.A. J. Clin. Invest. (1991) [Pubmed]
  3. The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. Davies, J., Warwick, J., Totty, N., Philp, R., Helfrich, M., Horton, M. J. Cell Biol. (1989) [Pubmed]
  4. A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C. Freed, E., Gailit, J., van der Geer, P., Ruoslahti, E., Hunter, T. EMBO J. (1989) [Pubmed]
  5. cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors. Suzuki, S., Argraves, W.S., Pytela, R., Arai, H., Krusius, T., Pierschbacher, M.D., Ruoslahti, E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  6. Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Isberg, R.R., Leong, J.M. Cell (1990) [Pubmed]
  7. A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells. Cheresh, D.A., Smith, J.W., Cooper, H.M., Quaranta, V. Cell (1989) [Pubmed]
  8. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Savill, J., Dransfield, I., Hogg, N., Haslett, C. Nature (1990) [Pubmed]
  9. An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2. Cheresh, D.A., Pytela, R., Pierschbacher, M.D., Klier, F.G., Ruoslahti, E., Reisfeld, R.A. J. Cell Biol. (1987) [Pubmed]
  10. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Cheresh, D.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  11. Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction. Gawaz, M., Neumann, F.J., Dickfeld, T., Reininger, A., Adelsberger, H., Gebhardt, A., Schömig, A. Circulation (1997) [Pubmed]
  12. Inhibition of bone resorption by 17beta-estradiol in human bone marrow cultures. Sarma, U., Edwards, M., Motoyoshi, K., Flanagan, A.M. J. Cell. Physiol. (1998) [Pubmed]
  13. Localisation of vitronectin receptor immunoreactivity and tartrate resistant acid phosphatase activity in synovium from patients with inflammatory or degenerative arthritis. Ashton, B.A., Ashton, I.K., Marshall, M.J., Butler, R.C. Ann. Rheum. Dis. (1993) [Pubmed]
  14. Acute cellular rejection following human heart transplantation is associated with increased expression of vitronectin receptor (integrin alphavbeta3). Yamani, M.H., Yang, J., Masri, C.S., Ratliff, N.B., Bond, M., Starling, R.C., McCarthy, P., Plow, E., Young, J.B. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2002) [Pubmed]
  15. Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. Sonnenberg, A., Linders, C.J., Modderman, P.W., Damsky, C.H., Aumailley, M., Timpl, R. J. Cell Biol. (1990) [Pubmed]
  16. An alternative cytoplasmic domain of the integrin beta 3 subunit. van Kuppevelt, T.H., Languino, L.R., Gailit, J.O., Suzuki, S., Ruoslahti, E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  17. Biogenesis of the vitronectin receptor in human endothelial cell: evidence that the vitronectin receptor and GPIIb-IIIa are synthesized by a common mechanism. Polack, B., Duperray, A., Troesch, A., Berthier, R., Marguerie, G. Blood (1989) [Pubmed]
  18. Integrin subunits responsible for adhesion of human osteoblast-like cells to biomimetic peptide surfaces. Rezania, A., Healy, K.E. J. Orthop. Res. (1999) [Pubmed]
  19. Interaction of osteopontin with osteoclast integrins. Horton, M.A., Nesbit, M.A., Helfrich, M.H. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
  20. Fibronectin receptors of phagocytes. Characterization of the Arg-Gly-Asp binding proteins of human monocytes and polymorphonuclear leukocytes. Brown, E.J., Goodwin, J.L. J. Exp. Med. (1988) [Pubmed]
  21. The mouse vitronectin receptor is a T cell activation antigen. Moulder, K., Roberts, K., Shevach, E.M., Coligan, J.E. J. Exp. Med. (1991) [Pubmed]
  22. Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis. da Costa, C.E., Annels, N.E., Faaij, C.M., Forsyth, R.G., Hogendoorn, P.C., Egeler, R.M. J. Exp. Med. (2005) [Pubmed]
  23. Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation. Singer, I.I., Scott, S., Kawka, D.W., Kazazis, D.M., Gailit, J., Ruoslahti, E. J. Cell Biol. (1988) [Pubmed]
  24. The GPIIB-IIIa-like complex may function as a human melanoma cell adhesion receptor for thrombospondin. Tuszynski, G.P., Karczewski, J., Smith, L., Murphy, A., Rothman, V.L., Knudsen, K.A. Exp. Cell Res. (1989) [Pubmed]
  25. Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis. Beacham, D.A., Wise, R.J., Turci, S.M., Handin, R.I. J. Biol. Chem. (1992) [Pubmed]
  26. Mechanisms of colon cancer binding to substratum and cells. Ebert, E.C. Dig. Dis. Sci. (1996) [Pubmed]
  27. The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin. Charo, I.F., Nannizzi, L., Smith, J.W., Cheresh, D.A. J. Cell Biol. (1990) [Pubmed]
  28. Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading. Bergman, M., Joukov, V., Virtanen, I., Alitalo, K. Mol. Cell. Biol. (1995) [Pubmed]
  29. Identification of a role of the vitronectin receptor and protein kinase C in the induction of endothelial cell vascular formation. Davis, C.M., Danehower, S.C., Laurenza, A., Molony, J.L. J. Cell. Biochem. (1993) [Pubmed]
  30. The distribution of distinct integrins in focal contacts is determined by the substratum composition. Fath, K.R., Edgell, C.J., Burridge, K. J. Cell. Sci. (1989) [Pubmed]
  31. Nuclear localization of type I parathyroid hormone/parathyroid hormone-related protein receptors in deer antler osteoclasts: evidence for parathyroid hormone-related protein and receptor activator of NF-kappaB-dependent effects on osteoclast formation in regenerating mammalian bone. Faucheux, C., Horton, M.A., Price, J.S. J. Bone Miner. Res. (2002) [Pubmed]
  32. Platelet glycoprotein IIb gene expression as a model of megakaryocyte-specific expression. Block, K.L., Poncz, M. Stem Cells (1995) [Pubmed]
  33. Colony stimulating factor-1-induced osteoclast spreading depends on substrate and requires the vitronectin receptor and the c-src proto-oncogene. Teti, A., Taranta, A., Migliaccio, S., Degiorgi, A., Santandrea, E., Villanova, I., Faraggiana, T., Chellaiah, M., Hruska, K.A. J. Bone Miner. Res. (1998) [Pubmed]
  34. The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23. Hermann, P., Armant, M., Brown, E., Rubio, M., Ishihara, H., Ulrich, D., Caspary, R.G., Lindberg, F.P., Armitage, R., Maliszewski, C., Delespesse, G., Sarfati, M. J. Cell Biol. (1999) [Pubmed]
  35. Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages. Serghides, L., Kain, K.C. J. Immunol. (2001) [Pubmed]
  36. Expression of adhesion molecules in Langerhans' cell histiocytosis. Ruco, L.P., Stoppacciaro, A., Vitolo, D., Uccini, S., Baroni, C.D. Histopathology (1993) [Pubmed]
  37. A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. Longhurst, C.M., White, M.M., Wilkinson, D.A., Jennings, L.K. Eur. J. Biochem. (1999) [Pubmed]
  38. Effect of eptifibatide for acute coronary syndromes: rapid versus late administration--therapeutic yield on platelets (The EARLY Platelet Substudy). Gurbel, P.A., Galbut, B., Bliden, K.P., Bahr, R.D., Roe, M.T., Serebruany, V.L., Gibler, W.B., Christenson, R.H., Ohman, E.M. J. Thromb. Thrombolysis (2002) [Pubmed]
  39. Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. Pankov, R., Cukierman, E., Katz, B.Z., Matsumoto, K., Lin, D.C., Lin, S., Hahn, C., Yamada, K.M. J. Cell Biol. (2000) [Pubmed]
WikiGenes - Universities