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Gene Review

Slamf7  -  SLAM family member 7

Mus musculus

Synonyms: 19A, 19A24, 4930560D03Rik, CRACC, CS1, ...
 
 
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Disease relevance of Slamf7

  • However, these Klebsiella polysaccharides did not react in immunodiffusion with horse or with rabbit pneumococcal 19F and 19A typing antisera [1].
  • Pneumococcal serotype 19F conjugate vaccine induces cross-protective immunity to serotype 19A in a murine pneumococcal pneumonia model [2].
  • Monoclonal antibodies (MAbs) against the different coli surface antigens CS1, CS2, and CS3 of colonization factor antigen II (CFA/II) of enterotoxigenic Escherichia coli (ETEC) were generated by fusing F/O myeloma cells with spleen cells from BALB/c mice immunized with different preparations of purified CFA/II [3].
  • Materials and Methods: The C57BL/6 mouse model of gastritis was used for infection with Helicobacter felis (CS1) or H. pylori (SS1) [4].
 

High impact information on Slamf7

  • Daily systemic injections of RGD, CS-1, and/or peptides derived from the heparin-binding region of the A chain not only prevented leukocyte infiltration in the salivary glands of the TGF-beta1 -/- mice, but also reversed the acinar and ductal derangements [5].
  • A mutant in the blpMN operon created in the clinically relevant type 19A background was deficient in both bacteriocin activity and immunity [6].
  • 2. Cyclo(-isoleucyl-leucyl-aspartyl-valyl-aminohexanoyl-) (c(ILDV-NH(CH2)5CO)) was approximately 5 fold more potent (IC50 3.6+/-0.44 microM) than the 25-amino acid linear CS-1 peptide [7].
  • However, whereas one MAb against CS3 was inhibited by all of 18 different CFA/II-positive strains tested, another anti-CS3 MAb was inhibited by bacteria expressing CS1 and CS3 (CS1 + CS3 strains) or CS3 alone but not by CS2 + CS3 strains, suggesting antigenic differences in CS3 when expressed by different strains [3].
  • Northern blot analysis revealed that the expression of mouse and human novel Ly9 was predominantly restricted to hematopoietic tissues, with the exception of testis [8].
 

Anatomical context of Slamf7

 

Associations of Slamf7 with chemical compounds

  • Five hybrids that produced antibodies specific for CS1, CS2, or CS3 in high titer were cloned and propagated [3].
  • Murine monoclonal antibodies against pneumococcal capsular polysaccharide types 4, 8, 22F and 19A/19F [11].
 

Analytical, diagnostic and therapeutic context of Slamf7

  • Active immunization with PNC and passive immunization with serum samples from infants vaccinated with PNC containing serotype 19F, but not serotype 19A, protected against lung infection caused by both serotypes in a murine model [2].
  • The multiplex serotyping assay consists of 24 assays specific for 36 serotypes: serotypes 1, 2, 3, 4, 5, 6A, 6B, 7A/7F, 8, 9L/9N, 9V, 10A/10B/39/(33C), 11A/11D/11F, 12A/12B/12F, 14, 15B/(15C), 17F, 18C, 19A, 19F, 20, 22A/22F, 23F, and 33A/33F [12].

References

  1. Immunochemical relations between pneumococcal group 19 and Klebsiella capsular polysaccharides. Lee, C.J., Koizumi, K. J. Immunol. (1981) [Pubmed]
  2. Pneumococcal serotype 19F conjugate vaccine induces cross-protective immunity to serotype 19A in a murine pneumococcal pneumonia model. Jakobsen, H., Sigurdsson, V.D., Sigurdardottir, S., Schulz, D., Jonsdottir, I. Infect. Immun. (2003) [Pubmed]
  3. Monoclonal antibodies against the different subcomponents of colonization factor antigen II of enterotoxigenic Escherichia coli. Lopez-Vidal, Y., Svennerholm, A.M. J. Clin. Microbiol. (1990) [Pubmed]
  4. Urea, fluorofamide, and omeprazole treatments alter helicobacter colonization in the mouse gastric mucosa. Aristoteli, L.P., O'rourke, J.L., Danon, S., Larsson, H., Mellgard, B., Mitchell, H., Lee, A. Helicobacter (2006) [Pubmed]
  5. Autoimmune Sjögren's-like lesions in salivary glands of TGF-beta1-deficient mice are inhibited by adhesion-blocking peptides. McCartney-Francis, N.L., Mizel, D.E., Redman, R.S., Frazier-Jessen, M., Panek, R.B., Kulkarni, A.B., Ward, J.M., McCarthy, J.B., Wahl, S.M. J. Immunol. (1996) [Pubmed]
  6. The blp Bacteriocins of Streptococcus pneumoniae Mediate Intraspecies Competition both In Vitro and In Vivo. Dawid, S., Roche, A.M., Weiser, J.N. Infect. Immun. (2007) [Pubmed]
  7. Anti-inflammatory activity of c(ILDV-NH(CH2)5CO), a novel, selective, cyclic peptide inhibitor of VLA-4-mediated cell adhesion. Haworth, D., Rees, A., Alcock, P.J., Wood, L.J., Dutta, A.S., Gormley, J.J., Jones, H.B., Jamieson, A., Reilly, C.F. Br. J. Pharmacol. (1999) [Pubmed]
  8. Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. Tovar, V., del Valle, J., Zapater, N., Martin, M., Romero, X., Pizcueta, P., Bosch, J., Terhorst, C., Engel, P. Immunogenetics (2002) [Pubmed]
  9. Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity. Nishina, H., Inageda, K., Takahashi, K., Hoshino, S., Ikeda, K., Katada, T. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  10. The role of CS1 moiety of fibronectin in VLA mediated haemopoietic progenitor trafficking. Craddock, C.F., Nakamoto, B., Elices, M., Papayannopoulou, T. Br. J. Haematol. (1997) [Pubmed]
  11. Murine monoclonal antibodies against pneumococcal capsular polysaccharide types 4, 8, 22F and 19A/19F. Kolberg, J., Aaberge, I.S., Jantzen, E., Løvik, M., Lermark, G., Steen, T. APMIS (1992) [Pubmed]
  12. Rapid multiplex assay for serotyping pneumococci with monoclonal and polyclonal antibodies. Yu, J., Lin, J., Benjamin, W.H., Waites, K.B., Lee, C.H., Nahm, M.H. J. Clin. Microbiol. (2005) [Pubmed]
 
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