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Gene Review

Kdm5b  -  lysine (K)-specific demethylase 5B

Mus musculus

Synonyms: 2010009J12Rik, 2210016I17Rik, AW556288, D1Ertd202e, Histone demethylase JARID1B, ...
 
 
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Disease relevance of Jarid1b

  • Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer [1].
  • PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis [2].
 

High impact information on Jarid1b

  • Using in situ hybridisation and immunostaining of testis sections we show that Plu-1 mRNA and PLU-1 protein are both highly expressed in the mitotic spermatogonia [2].
  • In previous studies, high levels of expression of Plu-1 mRNA and PLU-1 protein were detected in breast cancers, while expression in normal adult tissues was detected only in the testis, ovary and transiently in the mammary gland of the pregnant female [2].
  • Due to its high levels of expression in the testis and to its specific relationship to cancer, PLU-1 has been proposed to belong to the family of testis-cancer antigens [2].
  • In this study we attempted to determine putative functions for PLU-1 during spermatogenesis [2].
  • As with human PLU-1 the expression of Plu-1 in adult tissues is restricted, with high expression being seen only in testis, while expression in mammary tumours from c-neu transgenic mice is high [1].
 

Biological context of Jarid1b

  • Two transcription start sites of the PLU-1 gene were mapped by 5' RACE [3].
  • To investigate the control of expression of the PLU-1 gene, we have cloned and functionally characterised the 5' flanking region of the gene, which was found to contain another putative gene [3].
  • We found that not only is the core promoter sufficient to activate transcription in vivo, but that the expression of the reporter gene coincides both temporally and spatially with regions where endogenous Plu-1 is highly expressed [3].
  • Thus Plu-1 appears to play an important role in mouse embryonic development which may involve interaction with Pax9 and Bf-1 [4].
 

Anatomical context of Jarid1b

  • Plu-1 is also differentially expressed in the adult mammary gland [1].
  • In the developing embryo Plu-1 is expressed in a temporally restricted fashion with tissue specific expression being limited to parts of the developing brain, whisker follicle, mammary bud, thymus, limbs, intervertebral disc, olfactory epithelium, teeth, eye, and stomach [1].
 

Analytical, diagnostic and therapeutic context of Jarid1b

  • Consistent with this notion, we found that PLU-1 is present in the chromatin fraction in biochemical cell fractionation experiments using both somatic and meiotic cells [2].

References

  1. Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. Madsen, B., Spencer-Dene, B., Poulsom, R., Hall, D., Lu, P.J., Scott, K., Shaw, A.T., Burchell, J.M., Freemont, P., Taylor-Papadimitriou, J. Mech. Dev. (2002) [Pubmed]
  2. PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis. Madsen, B., Tarsounas, M., Burchell, J.M., Hall, D., Poulsom, R., Taylor-Papadimitriou, J. Chromosoma (2003) [Pubmed]
  3. A short region of the promoter of the breast cancer associated PLU-1 gene can regulate transcription in vitro and in vivo. Catteau, A., Rosewell, I., Solomon, E., Taylor-Papadimitriou, J. Int. J. Oncol. (2004) [Pubmed]
  4. Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. Madsen, B., Spencer-Dene, B., Poulsom, R., Hall, D., Lu, P.J., Scott, K., Shaw, A.T., Burchell, J.M., Freemont, P., Taylor-Papadimitriou, J. Gene Expr. Patterns (2002) [Pubmed]
 
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