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Ncapg2  -  non-SMC condensin II complex, subunit G2

Mus musculus

Synonyms: 5830426I05Rik, CAP-G2, Chromosome-associated protein G2, Condensin-2 complex subunit G2, Leucine zipper protein 5, ...
 
 
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Disease relevance of Ncapg2

  • 4. Herein we report that Mtb 8.4-specific T cells can be detected in mice immunized with the current live attenuated vaccine, Mycobacterium bovis-bacillus Calmette-Guérin as well as in mice infected i.v. with M. tuberculosis [1].
  • The gene (Mtb 8.4) corresponding to the identified polypeptide was cloned, sequenced, and expressed in Escherichia coli [2].
  • The downregulation was specific for live virulent Mtb, while live BCG, heat killed Mtb and latex beads-mediated phagocytosis did not affect the transcriptional level of this enzyme [3].
  • Novel Bacterial Delivery System with Attenuated Salmonella typhimurium Carrying Plasmid Encoding Mtb Antigen 85A for Mucosal Immunization: Establishment of Proof of Principle in TB Mouse Model [4].
  • RESULTS: While TNF-KO mice succumbed to infection within 4-5 weeks, mem-TNF mice recruited normally T cells and macrophages, developed mature granuloma in the lung and controlled acute Mtb infection [5].
 

High impact information on Ncapg2

  • Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb [6].
  • Furthermore, Mtb(-/-) blastocysts exhibited a higher frequency of apoptotic cells than wild-type or heterozygous blastocysts [7].
  • Surprisingly, embryos with a targeted disruption of Mtb died prior to the initiation of blood cell development, immediately following implantation [7].
  • These findings demonstrate that Mtb is a novel gene that is essential for early embryonic development [7].
  • More than blood (Mtb) is a novel gene that is widely expressed in mouse embryos prior to gastrulation but is subsequently restricted to specific tissues, including the developing central nervous system and hematopoietic organs [7].
 

Biological context of Ncapg2

  • More importantly, immunization of mice with either plasmid DNA encoding Mtb 8.4 or Mtb 8.4 recombinant protein formulated with IFA elicited strong CD4(+) T cell and CD8(+) CTL responses and induced protection on challenge with virulent M. tuberculosis [1].
 

Anatomical context of Ncapg2

  • Reconstitution of irradiated TNF-KO mice with mem-TNF derived bone marrow cells, but not with lymphocytes, conferred host resistance to Mtb infection in TNF-KO mice [5].
 

Analytical, diagnostic and therapeutic context of Ncapg2

  • Vaccination with the T cell antigen Mtb 8.4 protects against challenge with Mycobacterium tuberculosis [1].
  • METHODS: C57BL/6, TNF KO and mem-TNF mice were infected with M. tuberculosis H37Rv (Mtb at 100 CFU by intranasal administration) and the survival, bacterial load, lung pathology and immunological parameters were investigated [5].

References

  1. Vaccination with the T cell antigen Mtb 8.4 protects against challenge with Mycobacterium tuberculosis. Coler, R.N., Campos-Neto, A., Ovendale, P., Day, F.H., Fling, S.P., Zhu, L., Serbina, N., Flynn, J.L., Reed, S.G., Alderson, M.R. J. Immunol. (2001) [Pubmed]
  2. Molecular cloning and immunologic reactivity of a novel low molecular mass antigen of Mycobacterium tuberculosis. Coler, R.N., Skeiky, Y.A., Vedvick, T., Bement, T., Ovendale, P., Campos-Neto, A., Alderson, M.R., Reed, S.G. J. Immunol. (1998) [Pubmed]
  3. Regulation of macrophage gene expression following invasion by Mycobacterium tuberculosis. Ragno, S., Estrada, I., Butler, R., Colston, M.J. Immunol. Lett. (1997) [Pubmed]
  4. Novel Bacterial Delivery System with Attenuated Salmonella typhimurium Carrying Plasmid Encoding Mtb Antigen 85A for Mucosal Immunization: Establishment of Proof of Principle in TB Mouse Model. Parida, S.K., Huygen, K., Ryffel, B., Chakraborty, T. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  5. Membrane TNF confers protection to acute mycobacterial infection. Fremond, C., Allie, N., Dambuza, I., Grivennikov, S.I., Yeremeev, V., Quesniaux, V.F., Jacobs, M., Ryffel, B. Respir. Res. (2005) [Pubmed]
  6. HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells. Heinzel, A.S., Grotzke, J.E., Lines, R.A., Lewinsohn, D.A., McNabb, A.L., Streblow, D.N., Braud, V.M., Grieser, H.J., Belisle, J.T., Lewinsohn, D.M. J. Exp. Med. (2002) [Pubmed]
  7. More than blood, a novel gene required for mammalian postimplantation development. Smith, E.D., Xu, Y., Tomson, B.N., Leung, C.G., Fujiwara, Y., Orkin, S.H., Crispino, J.D. Mol. Cell. Biol. (2004) [Pubmed]
 
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