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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Sun1  -  Sad1 and UNC84 domain containing 1

Mus musculus

Synonyms: 4632417G13Rik, 5730434D03Rik, Protein unc-84 homolog A, SUN domain-containing protein 1, Sad1/unc-84 protein-like 1, ...
 
 
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High impact information on Unc84a

  • The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2 [1].
  • Codepletion of both of these proteins in HeLa cells leads to the loss of ONM-associated nesp2G, as does overexpression of the Sun1 lumenal domain [1].
  • We show that a direct association of their highly conserved C-terminal luminal domain with the inner nuclear membrane protein Sun1 mediates their nuclear envelope localisation [2].
  • Our findings propose a conserved nuclear anchorage mechanism between Caenorhabditis elegans and mammals and suggest a model in which Sun1 serves as a ;structural bridge' connecting the nuclear interior with the actin cytoskeleton [2].
 

Other interactions of Unc84a

  • In this study, we confirm and extend these results by demonstrating that both Sun1 and Sun2 contribute to nesp2G localization [1].

References

  1. Coupling of the nucleus and cytoplasm: role of the LINC complex. Crisp, M., Liu, Q., Roux, K., Rattner, J.B., Shanahan, C., Burke, B., Stahl, P.D., Hodzic, D. J. Cell Biol. (2006) [Pubmed]
  2. The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. Padmakumar, V.C., Libotte, T., Lu, W., Zaim, H., Abraham, S., Noegel, A.A., Gotzmann, J., Foisner, R., Karakesisoglou, I. J. Cell. Sci. (2005) [Pubmed]
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