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Gene Review

ZNF224  -  zinc finger protein 224

Homo sapiens

Synonyms: BMZF-2, BMZF2, Bone marrow zinc finger 2, KOX22, ZNF233, ...
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High impact information on ZNF224


Biological context of ZNF224

  • We demonstrate that ZNF224, a Kruppel-like zinc finger transcription factor, is the repressor protein that specifically binds to the negative cis-element AldA-NRE and affects the AldA-NRE-mediated transcription [4].
  • A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inhibits gene expression [4].
  • Using chromatin immunoprecipitation and transient transfection assays, we demonstrate that ZNF224 binds in vivo to the distal promoter of the aldolase A gene and represses its transcription [3].

Associations of ZNF224 with chemical compounds

  • We recently purified ZNF224, a new Krüppel-like zinc finger protein, that contains a Krüppel-associated box (KRAB) domain at the NH2 terminus, and 19 Cys2-His2 zinc-finger domains at the COOH terminus [3].

Other interactions of ZNF224


Analytical, diagnostic and therapeutic context of ZNF224


  1. Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor. Lee, T.H., Lwu, S., Kim, J., Pelletier, J. J. Biol. Chem. (2002) [Pubmed]
  2. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. Han, Z.G., Zhang, Q.H., Ye, M., Kan, L.X., Gu, B.W., He, K.L., Shi, S.L., Zhou, J., Fu, G., Mao, M., Chen, S.J., Yu, L., Chen, Z. J. Biol. Chem. (1999) [Pubmed]
  3. The Krüppel-like zinc-finger protein ZNF224 represses aldolase A gene transcription by interacting with the KAP-1 co-repressor protein. Medugno, L., Florio, F., De Cegli, R., Grosso, M., Lupo, A., Costanzo, P., Izzo, P. Gene (2005) [Pubmed]
  4. A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inhibits gene expression. Medugno, L., Costanzo, P., Lupo, A., Monti, M., Florio, F., Pucci, P., Izzo, P. FEBS Lett. (2003) [Pubmed]
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