High impact information on Fbxo43

• Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20 [1].
• Reduction of Emi2 released mature mII oocytes from cytostatic arrest, frequently inducing cytodegeneration [1].
• These studies show in intact oocytes that the interaction of Emi2 with Cdc20 links activating stimuli to meiotic resumption at fertilization and during parthenogenesis in mammals [1].
• Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis [2].

Biological context of Fbxo43

• Recombinant Emi2 reduced the propensity of mII oocytes to exit meiosis in response to activating stimuli [1].
• Depletion in situ of Emi2 by RNA interference elicited precocious meiotic exit in maturing mouse oocytes [1].

References