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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Sp2  -  Sp2 transcription factor

Mus musculus

Synonyms: 4930480I16Rik, Kiaa0048, Transcription factor Sp2, mKIAA0048
 
 
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Disease relevance of Sp2

 

High impact information on Sp2

  • By limited proteolysis with mouse submaxillaris protease, human prostatic acid phosphatase (EC 3.1.3.2) was cleaved into three fragments, Sp1, Sp2, and Sp3, which individually had no enzymatic activity [2].
  • Anti-Tac Fab'-Jun and anti-CD3 Fab'-Fos were expressed individually as F(ab'-zipper)2 homodimers in the mouse myeloma cell line Sp2/0 [3].
  • In three cases (Sp1, Sp2 and Sp7) it is shown that only the specific H and L combination has activity and that the myeloma chains are unable to substitute for them [4].
 

Associations of Sp2 with chemical compounds

  • The three antigens evaluated (Sp1, Sp2 and Sp3) were highly adsorbed by aluminum hydroxide adjuvant, but not adsorbed by aluminum phosphate adjuvant [5].

References

  1. A human monoclonal antibody HMD4 against ovarian carcinoma associated antigen. Cui, H., Qian, H.N., Feng, J., Fu, T.Y., Wei, P., Fu, Z.Y. Chin. Med. J. (1990) [Pubmed]
  2. A single domain of human prostatic acid phosphatase shows antibody-mediated restoration of catalytic activity. Choe, B.K., Dong, M.K., Walz, D., Gleason, S., Rose, N.R. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  3. Formation of a bispecific antibody by the use of leucine zippers. Kostelny, S.A., Cole, M.S., Tso, J.Y. J. Immunol. (1992) [Pubmed]
  4. Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Köhler, G., Milstein, C. Eur. J. Immunol. (1976) [Pubmed]
  5. Association Between Immunogenicity and Adsorption of a Recombinant Streptococcus pneumoniae Vaccine Antigen by an Aluminum Adjuvant. Levesque, P.M., Foster, K., de Alwis, U. Human vaccines. (2006) [Pubmed]
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