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Scn9a  -  sodium channel, voltage-gated, type IX,...

Rattus norvegicus

Synonyms: Nav1.7, PN1, Peripheral sodium channel 1, Scn2a, Sodium channel protein type 9 subunit alpha, ...
 
 
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Disease relevance of Scn9a

 

High impact information on Scn9a

  • Studies using cultured PC12 cells indicate that both expression and targeting of PN1 is induced by treatment of the cells with nerve growth factor [1].
  • In contrast to conventional signaling by growth factors that requires their continual presence, a 1-min pulse of nerve growth factor (NGF) is sufficient to induce electrical excitability in PC12 cells due to induction of the peripheral nerve type 1 (PN1) sodium channel gene [2].
  • Prevention of the elevation of intracellular Ca2+ levels using BAPTA-AM results in a block of PN1 induction by NGF [2].
  • Unlike rBIIa, the inactivation kinetics of PN1 are not accelerated by the coexpression of the beta-subunits [3].
  • Here, we report the cloning from rat, dorsal root ganglia (DRG), cellular expression, and functional analysis of a novel tetrodotoxin-sensitive peripheral sodium channel (PN), PN1 [3].
 

Anatomical context of Scn9a

  • In Xenopus oocytes, PN1 exhibits kinetics that are similar to rBIIa sodium currents and is inhibited by tetrodotoxin with an IC50 of 4.3 +/- 0.92 nM [3].
  • In pancreas, total ghrelin and obestatin concentrations decreased progressively from PN1 to PN21 but acylated ghrelin concentrations increased 6-7 times from F20 (18 [6] pg/ml) to PN6 (122 [59] pg/ml) [4].
 

Analytical, diagnostic and therapeutic context of Scn9a

  • Data from reverse transcription-polymerase chain reaction and sequence analyses of human DRG and other human tissues suggest that rat PN1 is an ortholog of the human neuroendocrine channel [3].

References

  1. Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Toledo-Aral, J.J., Moss, B.L., He, Z.J., Koszowski, A.G., Whisenand, T., Levinson, S.R., Wolf, J.J., Silos-Santiago, I., Halegoua, S., Mandel, G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Sustained signaling by phospholipase C-gamma mediates nerve growth factor-triggered gene expression. Choi, D.Y., Toledo-Aral, J.J., Segal, R., Halegoua, S. Mol. Cell. Biol. (2001) [Pubmed]
  3. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. Sangameswaran, L., Fish, L.M., Koch, B.D., Rabert, D.K., Delgado, S.G., Ilnicka, M., Jakeman, L.B., Novakovic, S., Wong, K., Sze, P., Tzoumaka, E., Stewart, G.R., Herman, R.C., Chan, H., Eglen, R.M., Hunter, J.C. J. Biol. Chem. (1997) [Pubmed]
  4. Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas. Chanoine, J.P., Wong, A.C., Barrios, V. Horm. Res. (2006) [Pubmed]
 
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