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Gene Review

Prx  -  periaxin

Rattus norvegicus

Synonyms: Periaxin
 
 
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Disease relevance of Prx

  • These findings support the hypothesis that Prx genes are regulated by changes in SMC adhesion and play key morphoregulatory roles during the development and progression of pulmonary vascular disease in adults [1].
  • The present study was conducted to evaluate the effects of GEB and HBA on the brain damage and transcriptional levels of Protein disulfide isomerase (PDI) and 1-Cys peroxiredoxin (1-Cys Prx) genes known to play a role in antioxidant systems after transient focal ischemia in the rat brain [2].
 

High impact information on Prx

 

Biological context of Prx

 

Anatomical context of Prx

 

Associations of Prx with chemical compounds

  • HBP23/Prx I induction by OA occurred on the transcriptional level as determined by studies with actinomycin D and nuclear run-off assays [7].
 

Other interactions of Prx

  • HBP23/Prx I has thioredoxin-dependent peroxidase activity and noncovalently binds the prooxidant heme with high affinity [7].

References

  1. Prx1 controls vascular smooth muscle cell proliferation and tenascin-C expression and is upregulated with Prx2 in pulmonary vascular disease. Jones, F.S., Meech, R., Edelman, D.B., Oakey, R.J., Jones, P.L. Circ. Res. (2001) [Pubmed]
  2. Gastrodia elata blume and an active component, p-hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions. Yu, S.J., Kim, J.R., Lee, C.K., Han, J.E., Lee, J.H., Kim, H.S., Hong, J.H., Kang, S.G. Biol. Pharm. Bull. (2005) [Pubmed]
  3. Periaxin, a novel protein of myelinating Schwann cells with a possible role in axonal ensheathment. Gillespie, C.S., Sherman, D.L., Blair, G.E., Brophy, P.J. Neuron (1994) [Pubmed]
  4. Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells. Parkinson, D.B., Dickinson, S., Bhaskaran, A., Kinsella, M.T., Brophy, P.J., Sherman, D.L., Sharghi-Namini, S., Duran Alonso, M.B., Mirsky, R., Jessen, K.R. Mol. Cell. Neurosci. (2003) [Pubmed]
  5. Regulation of 1-cys peroxiredoxin expression in lung epithelial cells. Kim, H.S., Pak, J.H., Gonzales, L.W., Feinstein, S.I., Fisher, A.B. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  6. Rat lung peroxiredoxins I and II are differentially regulated during development and by hyperoxia. Kim, H.S., Kang, S.W., Rhee, S.G., Clerch, L.B. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  7. Induction of heme-binding protein 23/peroxiredoxin I gene expression by okadaic acid in cultured rat hepatocytes. Immenschuh, S., Iwahara, S., Schwennen, B. DNA Cell Biol. (2002) [Pubmed]
  8. Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system. Mizusawa, H., Ishii, T., Bannai, S. Neurosci. Lett. (2000) [Pubmed]
 
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