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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Senp2  -  Sumo1/sentrin/SMT3 specific peptidase 2

Rattus norvegicus

Synonyms: Axam, Axin-associating molecule, Sentrin-specific protease 2, Sentrin/SUMO-specific protease SENP2
 
 
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High impact information on Senp2

  • On substitution of Ser for Cys(547) in the catalytic domain, Axam lost its desumoylation activity [1].
  • Over-expression of XSENP1 in vivo inhibited dorso-anterior development of Xenopus embryos and suppressed Wnt signalling target gene expression in a manner similar to Axam [2].

References

  1. Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. Kadoya, T., Yamamoto, H., Suzuki, T., Yukita, A., Fukui, A., Michiue, T., Asahara, T., Tanaka, K., Asashima, M., Kikuchi, A. Mol. Cell. Biol. (2002) [Pubmed]
  2. XSENP1, a novel sumo-specific protease in Xenopus, inhibits normal head formation by down-regulation of Wnt/beta-catenin signalling. Yukita, A., Michiue, T., Fukui, A., Sakurai, K., Yamamoto, H., Ihara, M., Kikuchi, A., Asashima, M. Genes Cells (2004) [Pubmed]
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