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Anxa6  -  annexin A6

Rattus norvegicus

Synonyms: Annexin A6, Annexin VI, Annexin-6, Anx6, CBP 65/67, ...
 
 
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Disease relevance of Anxa6

  • Neurofilaments were treated with chymotrypsin or with Staphylococcus aureus V8 protease (V8 protease) and the proteolytic fragments in soluble and particulate centrifugal fractions were identified by immune blotting, using antibodies raised against the Mr = 68,000 (P68), 145,000 (P145), and 200,000 (P200) subunits [1].
  • Late endocytic compartments are major sites of annexin VI localization in NRK fibroblasts and polarized WIF-B hepatoma cells [2].
  • The P70 group ate 21% less than the P14 rats (P < 0.001) and gained less body weight (P < 0.01) [3].
  • Hypoxic chemoreflex was assessed in P3 rats by acute exposure to 60% O(2) and in P20 or P70 rats by moderate hypoxia (12% O(2), 30 min) [4].
  • These findings suggest that the above protein changes are not an indirect offshoot of secondary stimulation of neurons by neurotransmitters or neuromodulators, and that P70 may contribute to the generation of epileptic seizure activities [5].
 

Psychiatry related information on Anxa6

 

High impact information on Anxa6

  • Males castrated at P28 and given testosterone implants retained exuberant dendritic length at P49; blank-implanted males had significantly shorter dendritic lengths by P70 [7].
  • Likewise, the three extracellular TAP were changed to two (P68 and P64) as a result of further glycosylation and subsequent secretion into the extracellular medium [8].
  • Identification of annexin VI as a Ca2+-sensitive CRHSP-28-binding protein in pancreatic acinar cells [9].
  • The interaction between CRHSP-28 and annexin VI was demonstrated by coimmunoprecipitation and gel-overlay assays and was shown to require low micromolar levels of free Ca(2+), indicating these molecules likely interact under physiological conditions [9].
  • In the present study, the Ca(2+)-sensitive phospholipid-binding protein annexin VI was purified from rat pancreas as a CRHSP-28-binding protein [9].
 

Chemical compound and disease context of Anxa6

  • Although the glycogen stores were decreased after hemorrhage glucose yield was increased (P70) and unchanged (P40) as compared to controls (Pc and Sc: 9) [10].
 

Biological context of Anxa6

  • In addition it suggests a mechanism for participation of annexin VI translocation that may underlie the alterations in macrophage function by oxidative stress [11].
  • The renin gene, beta-2 glycoprotein-1, retinol binding protein, annexin VI, and the PTP2C protein tyrosine phosphatase were among the downregulated genes [12].
  • Epinephrine was found to enhance the amplitude of the P70 component of the auditory evoked response in rats [13].
  • The offspring were examined on the 19th d of gestation (E19), the day of birth (P0), and at postnatal (P) day of life P3, P7, P14, P21, and P68 [14].
  • Behavior and food intake data were affected in P70 rats on d 1 of eating the very high protein diet and then returned to baseline values as early as d 2 of consuming the P70 diet [3].
 

Anatomical context of Anxa6

 

Associations of Anxa6 with chemical compounds

 

Other interactions of Anxa6

  • Finally, the expression of annexins I, II, IV and VI was studied: annexin I was equally distributed between MVBs and CURL; annexin II was highly enriched in RRC (95%), annexin IV was equally distributed between CURL and RRC, and annexin VI was enriched in CURL (57%) [19].
  • Antibody was produced against the annexin consensus peptide, Lys-Ala-Met-Lys-Gly-Leu-Gly-Thr-Asp-Glu, which was derived from the sequence of several Ca2+/phospholipid-binding proteins including calpactin, lipocortin, endonexin II, 67-kDa calelectrin, lymphocyte 68-kDa protein, and protein II [20].
  • Consistent with this, annexin VI was predominantly seen on structures that contained the lysosomal protein lgp120, although not on dense core lysosomes by electron microscopy [2].
  • These proteins were identified as protein kinase C alpha (80 kDa) and annexin VI (68 kDa) from the partial amino-acid sequencing, and neurocalcin alpha (22 kDa) and calmodulin (21 kDa) with western blotting and electrophoretic mobilities in the presence or absence of Ca(2+) ions [21].
  • Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain [22].
 

Analytical, diagnostic and therapeutic context of Anxa6

  • Immunofluorescence microscopy confirmed a dual localization of CRHSP-28 and annexin VI, which appeared in a punctate pattern in the supranuclear and apical cytoplasm of acini [9].
  • Extracellular TAP were detected by immunoblotting and immunoprecipitation techniques as two polypeptides (P68 and P64) [8].
  • Using a highly specific antibody, we have studied the distribution of annexin VI in NRK fibroblasts and the polarized hepatic cell line WIF-B by confocal microscopy [2].
  • Further characterization of the two proteins by peptide mapping and immunological methods revealed that the S1 protein belonged to a family of proteins related to the 70-kDa heat shock protein, whereas the S2 protein was identical to 68-kDa calelectrin (annexin VI) [23].
  • The effect of 70-kD protein (P70, a specific protein found in cobalt-induced epileptogenic focus of rat cerebral cortex) on membrane properties was examined in identified neurons of the snail, Euhadra peliomphala, using the pressure injection method combined with the voltage-clamp technique [24].

References

  1. The distribution of phosphorylation sites among identified proteolytic fragments of mammalian neurofilaments. Julien, J.P., Mushynski, W.E. J. Biol. Chem. (1983) [Pubmed]
  2. Late endocytic compartments are major sites of annexin VI localization in NRK fibroblasts and polarized WIF-B hepatoma cells. Pons, M., Ihrke, G., Koch, S., Biermer, M., Pol, A., Grewal, T., Jäckle, S., Enrich, C. Exp. Cell Res. (2000) [Pubmed]
  3. A very high 70%-protein diet does not induce conditioned taste aversion in rats. L'Heureux-Bouron, D., Tomé, D., Bensaid, A., Morens, C., Gaudichon, C., Fromentin, G. J. Nutr. (2004) [Pubmed]
  4. Prenatal blockade of estradiol synthesis impairs respiratory and metabolic responses to hypoxia in newborn and adult rats. Doan, V.D., Gagnon, S., Joseph, V. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  5. Protein changes associated with cobalt-induced epileptic activity in rat cerebral cortex. Imai, S., Onozuka, M. Epilepsy Res. (1991) [Pubmed]
  6. Preliminary evidence for methamphetamine-induced behavioral and ocular effects in rat offspring following exposure during early organogenesis. Acuff-Smith, K.D., George, M., Lorens, S.A., Vorhees, C.V. Psychopharmacology (Berl.) (1992) [Pubmed]
  7. Androgen regulation of dendritic growth and retraction in the development of a sexually dimorphic spinal nucleus. Goldstein, L.A., Kurz, E.M., Sengelaub, D.R. J. Neurosci. (1990) [Pubmed]
  8. Secretion, glycosylation, and phosphorylation of rat-specific, transformation-associated proteins in Moloney murine sarcoma virus-transformed rat cells. Li, W.J., Chan, J.C. Cancer Res. (1989) [Pubmed]
  9. Identification of annexin VI as a Ca2+-sensitive CRHSP-28-binding protein in pancreatic acinar cells. Thomas, D.D., Kaspar, K.M., Taft, W.B., Weng, N., Rodenkirch, L.A., Groblewski, G.E. J. Biol. Chem. (2002) [Pubmed]
  10. Hypovolemic stress-induced glycogenolysis. Isolated liver perfusion study. Boija, P.O., Ljungqvist, O., Nylander, G., Ware, J. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1987) [Pubmed]
  11. Hydroperoxide-induced increases in intracellular calcium due to annexin VI translocation and inactivation of plasma membrane Ca2+-ATPase. Hoyal, C.R., Thomas, A.P., Forman, H.J. J. Biol. Chem. (1996) [Pubmed]
  12. A gene expression analysis in rat kidney following high and low salt intake. Barta, P., Monti, J., Maass, P.G., Gorzelniak, K., Müller, D.N., Dechend, R., Luft, F.C., Hübner, N., Sharma, A.M. J. Hypertens. (2002) [Pubmed]
  13. Blockade of epinephrine priming of the cerebral auditory evoked response by cortical cholinergic deafferentation. Berntson, G.G., Shafi, R., Knox, D., Sarter, M. Neuroscience (2003) [Pubmed]
  14. Long-term prenatal hypoxia alters maturation of adrenal medulla in rat. Mamet, J., Peyronnet, J., Roux, J.C., Perrin, D., Cottet-Emard, J.M., Pequignot, J.M., Lagercrantz, H., Dalmaz, Y. Pediatr. Res. (2002) [Pubmed]
  15. Molecular characterization of phagosomes. Desjardins, M., Celis, J.E., van Meer, G., Dieplinger, H., Jahraus, A., Griffiths, G., Huber, L.A. J. Biol. Chem. (1994) [Pubmed]
  16. Differential expression of annexins I-VI in the rat dorsal root ganglia and spinal cord. Naciff, J.M., Kaetzel, M.A., Behbehani, M.M., Dedman, J.R. J. Comp. Neurol. (1996) [Pubmed]
  17. Modulation of Ca2+ release channel activity from sarcoplasmic reticulum by annexin VI (67-kDa calcimedin). Díaz-Muñoz, M., Hamilton, S.L., Kaetzel, M.A., Hazarika, P., Dedman, J.R. J. Biol. Chem. (1990) [Pubmed]
  18. Annexin VI, a marker protein of hepatocytic endosomes. Jäckle, S., Beisiegel, U., Rinninger, F., Buck, F., Grigoleit, A., Block, A., Gröger, I., Greten, H., Windler, E. J. Biol. Chem. (1994) [Pubmed]
  19. Identification of cytoskeleton-associated proteins in isolated rat liver endosomes. Pol, A., Ortega, D., Enrich, C. Biochem. J. (1997) [Pubmed]
  20. Differential tissue expression of three 35-kDa annexin calcium-dependent phospholipid-binding proteins. Kaetzel, M.A., Hazarika, P., Dedman, J.R. J. Biol. Chem. (1989) [Pubmed]
  21. Calcium-dependent association of annexin VI, protein kinase C alpha, and neurocalcin alpha on the raft fraction derived from the synaptic plasma membrane of rat brain. Orito, A., Kumanogoh, H., Yasaka, K., Sokawa, J., Hidaka, H., Sokawa, Y., Maekawa, S. J. Neurosci. Res. (2001) [Pubmed]
  22. Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. Chow, A., Davis, A.J., Gawler, D.J. FEBS Lett. (2000) [Pubmed]
  23. Two 68-kDa proteins in slow axonal transport belong to the 70-kDa heat shock protein family and the annexin family. Sekimoto, S., Tashiro, T., Komiya, Y. J. Neurochem. (1991) [Pubmed]
  24. A specific 70K protein found in epileptic rat cortex: induction of bursting activity and negative resistance by its intracellular application in Euhadra neurons. Onozuka, M., Imai, S., Furuichi, H., Ozono, S. J. Neurobiol. (1991) [Pubmed]
 
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