The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

BAG6  -  BCL2-associated athanogene 6

Homo sapiens

Synonyms: BAG family molecular chaperone regulator 6, BAG-6, BAT3, D6S52E, G3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BAT3


Psychiatry related information on BAT3

  • Using a 3-generation, prospective study design, we examine the level of behavioral continuity between Generation 2 (G2) and Generation 3 (G3), and the role of economic disadvantage and parenting behaviors as mediating links [6].

High impact information on BAT3


Chemical compound and disease context of BAT3

  • The aim of the study was to determine the effects on the transport of propranolol across monolayers of the human colon adenocarcinoma cell line, Caco-2, of forming a prodrug by conjugating to generation 3 (G3) and lauroyl-G3 PAMAM dendrimers [11].

Biological context of BAT3


Anatomical context of BAT3

  • Green fluorescent protein-tagged BAT3 was largely localized in the cytoplasm of COS cells [14].
  • Northern hybridization showed that BAT3 mRNA was expressed in all the adult rat tissues examined but predominantly in testis [14].
  • The cycle period of the timing network and the phase difference between the ipsilateral G3 and G4 oscillator interneurons were regular within individual preparations, but varied among preparations [1].
  • Although the expression and function of HLA-G2, G3, G4 and G7 has previously been a matter of debate, until now it has been generally accepted that soluble HLA-G5 and HLA-G6 are both expressed and secreted by trophoblast [16].
  • The volumes and surface areas of the rough-surfaced endoplasmic reticulum (rER) and lysosomes per cell decreased progressively from G1 to G3 tumor cells [17].

Associations of BAT3 with chemical compounds

  • Cells from G3 tumours mainly used an alpha(3)beta(1) integrin complex for adhesion to mouse Ln-1 and to human Ln-1 and Ln-10 [18].
  • Proteins expressed from constructs containing the putative aggrecan signal sequence (i.e., the first 23 N-terminal amino acids), specified globular (G) domains G1 and/or G3, and a segment of the CS domain were detected in the endoplasmic reticulum (ER) and Golgi complex [19].
  • Conjugation of propranolol to lauroyl-G3 dendrimers further increased its A-->B P(app) [11].
  • Thirty-five consecutive patients presenting with T1 G3 tumours were treated with intravesical BCG [20].
  • An interim analysis showed that G3 PPE occurred in 5/16 pts treated with the 28-day infusional 5-FU schedule at the 3 dose levels [21].

Other interactions of BAT3

  • Through a fine mapping using markers of the HLA central region a preferential recombination site was localized in the 60 kilobase interval between TNFd,e, and D6S273/K11 Amicrosatellite loci (i.e., between LST1 and BAT3 genes) [22].
  • The deletion experiment revealed that the N-terminal region (amino acid residues 1-80) of DAN was required for the interaction with BAT3 [14].
  • The BAT3 and TNF-beta probes each detected two allelic bands with Taq I and Nco I digestion, respectively; the R5A and M20A probes each detected three polymorphic allelic bands with BstEII digestion [13].
  • Other protein isoforms (G2, G3 and G6), all containing the leader peptide and the alpha1 domain, are possible and their messenger mRNAs were found; any of these may undertake the necessary HLA-G functions [23].
  • The histology was Grade 1 (G1) in 36, Grade 2 (G2) in 18, Grade 3 (G3) in 28, and unknown in 19 patients [24].

Analytical, diagnostic and therapeutic context of BAT3


  1. Phase relationships between segmentally organized oscillators in the leech heartbeat pattern generating network. Masino, M.A., Calabrese, R.L. J. Neurophysiol. (2002) [Pubmed]
  2. Improving inter-observer agreement and certainty level in diagnosing and grading papillary urothelial neoplasms: usefulness of a Bayesian belief network. Montironi, R., Mazzucchelli, R., Colanzi, P., Streccioni, M., Scarpelli, M., Thompson, D., Bartels, P.H. Eur. Urol. (2002) [Pubmed]
  3. nm23 protein expression in fine-needle aspirates from breast carcinoma: inverse correlation with cytologic grading, lymph node status, and ploidy. Sauer, T., Furu, I., Beraki, K., Jebsen, P.W., Ormerod, E., Naess, O. Cancer (1998) [Pubmed]
  4. Survival and progression in high grade tumour subset of G2 and G3 pT1 bladder transitional cell carcinoma. Kamel, M.H., Daly, P.J., Khan, M.F., Kay, E.W., O'kelly, P., Hickey, D.P. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (2006) [Pubmed]
  5. Immunohistochemical analysis of endometrial adenocarcinoma for bcl-2 and p53 in relation to expression of sex steroid receptor and proliferative activity. Yamauchi, N., Sakamoto, A., Uozaki, H., Iihara, K., Machinami, R. Int. J. Gynecol. Pathol. (1996) [Pubmed]
  6. Linked lives: the intergenerational transmission of antisocial behavior. Thornberry, T.P., Freeman-Gallant, A., Lizotte, A.J., Krohn, M.D., Smith, C.A. Journal of abnormal child psychology. (2003) [Pubmed]
  7. A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain. Banerji, J., Sands, J., Strominger, J.L., Spies, T. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  8. Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3. Wu, Y.H., Shih, S.F., Lin, J.Y. J. Biol. Chem. (2004) [Pubmed]
  9. Identification of the motif in versican G3 domain that plays a dominant-negative effect on astrocytoma cell proliferation through inhibiting versican secretion and binding. Wu, Y., Zhang, Y., Cao, L., Chen, L., Lee, V., Zheng, P.S., Kiani, C., Adams, M.E., Ang, L.C., Paiwand, F., Yang, B.B. J. Biol. Chem. (2001) [Pubmed]
  10. Phenotype-based identification of host genes required for replication of African swine fever virus. Chang, A.C., Zsak, L., Feng, Y., Mosseri, R., Lu, Q., Kowalski, P., Zsak, A., Burrage, T.G., Neilan, J.G., Kutish, G.F., Lu, Z., Laegreid, W., Rock, D.L., Cohen, S.N. J. Virol. (2006) [Pubmed]
  11. The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. D'Emanuele, A., Jevprasesphant, R., Penny, J., Attwood, D. Journal of controlled release : official journal of the Controlled Release Society. (2004) [Pubmed]
  12. Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDM. Degli-Esposti, M.A., Abraham, L.J., McCann, V., Spies, T., Christiansen, F.T., Dawkins, R.L. Immunogenetics (1992) [Pubmed]
  13. Association of four HLA class III region genomic markers with HLA haplotypes. Pei, J., Choo, S.Y., Spies, T., Strominger, J.L., Hansen, J.A. Tissue Antigens (1991) [Pubmed]
  14. Cloning and characterization of rat BAT3 cDNA. Ozaki, T., Hanaoka, E., Naka, M., Nakagawara, A., Sakiyama, S. DNA Cell Biol. (1999) [Pubmed]
  15. A genomewide analysis of genes for the heat shock protein 70 chaperone system in the ascidian Ciona intestinalis. Wada, S., Hamada, M., Satoh, N. Cell Stress Chaperones (2006) [Pubmed]
  16. Does 'soluble' HLA-G really exist? Another twist to the tale. Sargent, I.L. Mol. Hum. Reprod. (2005) [Pubmed]
  17. Evaluation of human bladder tumors by ultrastructural morphometric techniques. Shimazui, T., Nemoto, R., Koiso, K., Uchiyama, Y. Virchows Arch., B, Cell Pathol. (1989) [Pubmed]
  18. Laminin alpha1 chain in human renal cell carcinomas and integrin-mediated adhesion of renal cell carcinoma cells to human laminin isoforms. Rissanen, J., Korhonen, M., Lehto, V.P., Virtanen, I. J. Pathol. (2003) [Pubmed]
  19. Aggrecan domains expected to traffic through the exocytic pathway are misdirected to the nucleus. Chen, T.L., Wang, P.Y., Luo, W., Gwon, S.S., Flay, N.W., Zheng, J., Guo, C., Tanzer, M.L., Vertel, B.M. Exp. Cell Res. (2001) [Pubmed]
  20. Low-dose BCG instillations in the treatment of stage T1 grade 3 bladder tumours: recurrence, progression and success. Lebret, T., Gaudez, F., Hervé, J.M., Barré, P., Lugagne, P.M., Botto, H. Eur. Urol. (1998) [Pubmed]
  21. An EORTC phase I study of epirubicin in combination with fixed doses of cyclophosphamide and infusional 5-fu (CEF-infu) as primary treatment of large operable or locally advanced/inflammatory breast cancer. Bonnefoi, H., Biganzoli, L., Cufer, T., Mauriac, L., Hamilton, A., Schaefer, P., Piccart, M. Breast Cancer Res. Treat. (2001) [Pubmed]
  22. The natural history of an HLA haplotype and its recombinants. D'Alfonso, S., Borelli, I., Dall'Omo, A., Bolognesi, E., Partanen, J., Levo, A., Pociot, F., Fan, L., Juji, T., Hammond, M., Tosi, R., Richiardi, P.M. Immunogenetics (1998) [Pubmed]
  23. Homozygous HLA-G*0105N healthy individuals indicate that membrane-anchored HLA-G1 molecule is not necessary for survival. Casro, M.J., Morales, P., Rojo-Amigo, R., Martinez-Laso, J., Allende, L., Varela, P., Garcia-Berciano, M., Guillen-Perales, J., Arnaiz-Villena, A. Tissue Antigens (2000) [Pubmed]
  24. Treatment results and prognostic factors in 101 men treated for squamous carcinoma of the penis. Sarin, R., Norman, A.R., Steel, G.G., Horwich, A. Int. J. Radiat. Oncol. Biol. Phys. (1997) [Pubmed]
  25. The human BAT3 ortholog in rodents is predominantly and developmentally expressed in testis. Wang, R., Liew, C.C. Mol. Cell. Biochem. (1994) [Pubmed]
  26. Temporomandibular disorders: clinical and laboratory analyses for risk assessment of criteria for surgical therapy, a pilot study. Halpern, L.R., Chase, D.C., Gerard, D.A., Behr, M.M., Jacobs, W. Cranio : the journal of craniomandibular practice. (1998) [Pubmed]
WikiGenes - Universities