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Gene Review:

Axin1 - axin 1

Rattus norvegicus

Synonyms: Axin, Axin-1, Axis inhibition protein 1, rAxin

Fukui, A. et al., Hirabayashi, S. et al., Lee, N.P. et al., Aschenbach, W.G. et al., Ikeda, S. et al.

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High impact information on Axin1

Furthermore, rAxin promoted GSK-3beta-dependent phosphorylation of beta-catenin [1].
The guanylate kinase domain of S-SCAM directly bound to the GSK3beta-binding region of Axin [2].
Immunoblotting demonstrated that Dvl, Axin, GSK-3beta, and beta-catenin proteins are expressed in rat red and white gastrocnemius muscles [3].
We thus undertook an investigation to study 3 adaptors in the seminiferous epithelium: zyxin, axin, and Wiskott-Aldrich syndrome protein (WASP) [4].
Histological examination and gene expression revealed that the ventralizing activity of the deltaDIX mutant was weaker than that of wild-type rAxin [5].

Biological context of Axin1

Thereby, S-SCAM inhibited the Axin-mediated phosphorylation of beta-catenin by GSK3beta [2].

Anatomical context of Axin1

Furthermore, an rAxin mutant that contained both the RGS and GSK3beta-binding domains affected both the dorsal and ventral sides of blastomeres, mediated ectodermal fate and induced expansion of notochord and/or endoderm, but did not induce axis formation [5].

References

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., Kikuchi, A. EMBO J. (1998) [Pubmed]
Synaptic scaffolding molecule interacts with axin. Hirabayashi, S., Nishimura, W., Iida, J., Kansaku, A., Kishida, S., Kikuchi, A., Tanaka, N., Hata, Y. J. Neurochem. (2004) [Pubmed]
Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Aschenbach, W.G., Ho, R.C., Sakamoto, K., Fujii, N., Li, Y., Kim, Y.B., Hirshman, M.F., Goodyear, L.J. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis. Lee, N.P., Mruk, D.D., Conway, A.M., Cheng, C.Y. J. Androl. (2004) [Pubmed]
Effects of rat Axin domains on axis formation in Xenopus embryos. Fukui, A., Kishida, S., Kikuchi, A., Asashima, M. Dev. Growth Differ. (2000) [Pubmed]

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AXIN1	Bos taurus
AXIN1	Canis lupus familiaris
axin1	Danio rerio
AXIN1	Gallus gallus
AXIN1	Homo sapiens
AXIN1	Macaca mulatta
Axin1	Mus musculus
AXIN1	Pan troglodytes
axin1	Xenopus (Silurana) tropicalis

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