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Gene Review

CENPU  -  centromere protein U

Homo sapiens

Synonyms: CENP-50, CENP-U, CENP50, CENPU50, Centromere protein U, ...
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Disease relevance of MLF1IP


High impact information on MLF1IP


Biological context of MLF1IP

  • The MLF1IP gene locus is at chromosome 4q35.1 and is composed of 14 exons spanning 75.8 kb of genomic DNA [1].
  • The MLF1IP cDNA encodes a 46-kDa protein that contains two bipartite and two classical nuclear localization signals, two nuclear receptor-binding motifs (LXXLL), two leucine zippers, two PEST residues and several potential phosphorylation sites [1].
  • We observed that the time for CENP-50-deficient cells to complete mitosis was longer than that for wild-type cells [3].
  • We also observed severe mitotic defects in CENP-50-deficient cells with apparent premature sister chromatid separation when the mitotic checkpoint was activated, indicating that CENP-50 is required for recovery from spindle damage [3].
  • Northern blot hybridization with a KLIP1 probe identified a major transcript of 1.8 kb and a minor transcript of 2.8 kb. cDNA library screening and 5'-RACE revealed that the major transcript encoded an open-reading-frame of 1,257 bp and had a 5'-untranslated region of 73 nucleotides [4].

Anatomical context of MLF1IP


Associations of MLF1IP with chemical compounds

  • A novel cellular protein KLIP1 was identified to interact with LNA through yeast two-hybrid screening, and confirmed by a glutathione S-transferase pull down assay [4].

Other interactions of MLF1IP

  • Centromeric localization of CENP-50 was abolished in both CENP-H- and CENP-I-deficient cells [3].


  1. cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP. Hanissian, S.H., Akbar, U., Teng, B., Janjetovic, Z., Hoffmann, A., Hitzler, J.K., Iscove, N., Hamre, K., Du, X., Tong, Y., Mukatira, S., Robertson, J.H., Morris, S.W. Oncogene (2004) [Pubmed]
  2. Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma. Hanissian, S.H., Teng, B., Akbar, U., Janjetovic, Z., Zhou, Q., Duntsch, C., Robertson, J.H. Brain Res. (2005) [Pubmed]
  3. The constitutive centromere component CENP-50 is required for recovery from spindle damage. Minoshima, Y., Hori, T., Okada, M., Kimura, H., Haraguchi, T., Hiraoka, Y., Bao, Y.C., Kawashima, T., Kitamura, T., Fukagawa, T. Mol. Cell. Biol. (2005) [Pubmed]
  4. Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus. Pan, H.Y., Zhang, Y.J., Wang, X.P., Deng, J.H., Zhou, F.C., Gao, S.J. J. Virol. (2003) [Pubmed]
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