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Gene Review

WDR26  -  WD repeat domain 26

Homo sapiens

Synonyms: CDW2, CUL4-and DDB1-associated WDR protein 2, FLJ21016, GID7, MIP2, ...
 
 
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Disease relevance of WDR26

 

High impact information on WDR26

  • Blockage of Egr-1 expression did not affect the upregulation of IL-6, HSP70, MIP-2, and itself by stretch [2].
  • A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells [3].
  • N(G)-Nitro-l-arginine methyl ester, an inhibitor of NO synthase, or 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, a scavenger of NO, augmented MIP-2 production on coculturing with early apoptotic cells [3].
  • Northern blot analysis indicates that WDR26 is expressed in most of the examined human tissues, especially at a high level in skeletal muscle [4].
  • These results suggest that WDR26 may act as a negative regulator in MAPK signaling pathway and play an important role in cell signal transduction [4].
 

Biological context of WDR26

 

Anatomical context of WDR26

 

Associations of WDR26 with chemical compounds

  • Interview with Dr. Yoshiro Kobayashi regarding Pivotal Advance: A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells [7].
  • Pre-treatment of hornfels and quartz particles </= 2 mum with aluminium lactate, to diminish the surface reactivity, did significantly reduce the MIP-2 response to hornfels [5].

References

  1. Mast cell chymase induces expression of chemokines for neutrophils in eosinophilic EoL-1 cells and mouse peritonitis eosinophils. Terakawa, M., Tomimori, Y., Goto, M., Fukuda, Y. Eur. J. Pharmacol. (2006) [Pubmed]
  2. Stretch-activated signaling pathways responsible for early response gene expression in fetal lung epithelial cells. Copland, I.B., Post, M. J. Cell. Physiol. (2007) [Pubmed]
  3. A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells. Shibata, T., Nagata, K., Kobayashi, Y. J. Leukoc. Biol. (2006) [Pubmed]
  4. WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway. Zhu, Y., Wang, Y., Xia, C., Li, D., Li, Y., Zeng, W., Yuan, W., Liu, H., Zhu, C., Wu, X., Liu, M. J. Cell. Biochem. (2004) [Pubmed]
  5. Different particle determinants induce apoptosis and cytokine release in primary alveolar macrophage cultures. Refsnes, M., Hetland, R.B., Ovrevik, J., Sundfør, I., Schwarze, P.E., Låg, M. Particle and fibre toxicology [electronic resource]. (2006) [Pubmed]
  6. Peritoneal application of chitosan and UV-cross-linkable chitosan. Yeo, Y., Burdick, J.A., Highley, C.B., Marini, R., Langer, R., Kohane, D.S. Journal of biomedical materials research. Part A. (2006) [Pubmed]
  7. Interview with Dr. Yoshiro Kobayashi regarding Pivotal Advance: A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells. Rosenberg, H.F., Oppenheim, J.J. J. Leukoc. Biol. (2006) [Pubmed]
 
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