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Cdk5rap3  -  CDK5 regulatory subunit associated protein 3

Mus musculus

Synonyms: 1810007E24Rik, BC002318, C53, C81486, CDK5 regulatory subunit-associated protein 3, ...
 
 
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Disease relevance of Cdk5rap3

  • In vivo treatment with free or nanoparticle-bound colistin did not significantly reduce the number of viable Salmonella C53, either in the liver or the spleen of infected mice [1].
 

High impact information on Cdk5rap3

  • The enzyme kinetics of the glutathione (GSH) conjugation of cryptophycin 52 (C52, R-stereoisomer) and cryptophycin 53 (C53, S-stereoisomer) by cytosolic glutathione S-transferases (cGSTs) from human, rat, mouse, dog and monkey liver were studied [2].
  • There was little GSH conjugation of C53 by cytosol or microsomes from any species [2].
  • Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53 [3].
  • Reporter assays demonstrated that C53 had little effect on CBP mediated transcriptional activation [3].
  • After repeated subcultures at 45 degrees C, isogenic variants harbouring the virulence-associated plasmid (strains C52, TM122 and TM332) or having lost this large plasmid (strains C53, TM123 and TM333) were obtained from three parental strains (strains C5, TM12 and TM33, respectively) [4].
 

Biological context of Cdk5rap3

  • Plasmid pIP1350, present in strain C52, was tagged by Tn10 and transferred by successive conjugations to strains C53, TM123 and TM333 [4].
 

Associations of Cdk5rap3 with chemical compounds

References

  1. Drug targeting by polyalkylcyanoacrylate nanoparticles is not efficient against persistent Salmonella. Page-Clisson, M.E., Pinto-Alphandary, H., Chachaty, E., Couvreur, P., Andremont, A. Pharm. Res. (1998) [Pubmed]
  2. In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S-transferase: species differences and stereoselectivity. Cannady, E.A., Chien, C., Jones, T.M., Borel, A.G. Xenobiotica (2006) [Pubmed]
  3. Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53. Yin, X., Warner, D.R., Roberts, E.A., Pisano, M.M., Greene, R.M. Int. J. Mol. Med. (2005) [Pubmed]
  4. Virulence-associated plasmids of Salmonella serotype Typhimurium in experimental murine infection. Pardon, P., Popoff, M.Y., Coynault, C., Marly, J., Miras, I. Ann. Inst. Pasteur Microbiol. (1986) [Pubmed]
 
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