Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

COX2 - cytochrome c oxidase subunit II

Naumovozyma castellii

Papadopoulou, B. et al., Mulero, J.J. et al., Fox, T.D., Clarkson, G.H. et al., Schulze, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on COX2

Using a gel mobility shift assay we show that a 40 kd protein (p40), present in extracts of yeast mitochondria, binds specifically to the 5'-untranslated leader of cytochrome c oxidase subunit II mRNA [1].
Five TGA "stop" codons occur within the translated sequence of the yeast mitochondrial gene for cytochrome c oxidase subunit II [2].
A role for membrane potential in the biogenesis of cytochrome c oxidase subunit II, a mitochondrial gene product [3].
SCO1, a yeast nuclear gene essential for accumulation of mitochondrial cytochrome c oxidase subunit II [4].

Biological context of COX2

PET111 is a yeast nuclear gene specifically required for the expression of the mitochondrial gene COX2, encoding cytochrome c oxidase subunit II (coxII) [5].

References

A 40 kd protein binds specifically to the 5'-untranslated regions of yeast mitochondrial mRNAs. Papadopoulou, B., Dekker, P., Blom, J., Grivell, L.A. EMBO J. (1990) [Pubmed]
Five TGA "stop" codons occur within the translated sequence of the yeast mitochondrial gene for cytochrome c oxidase subunit II. Fox, T.D. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
A role for membrane potential in the biogenesis of cytochrome c oxidase subunit II, a mitochondrial gene product. Clarkson, G.H., Poyton, R.O. J. Biol. Chem. (1989) [Pubmed]
SCO1, a yeast nuclear gene essential for accumulation of mitochondrial cytochrome c oxidase subunit II. Schulze, M., Rödel, G. Mol. Gen. Genet. (1988) [Pubmed]
PET111 acts in the 5'-leader of the Saccharomyces cerevisiae mitochondrial COX2 mRNA to promote its translation. Mulero, J.J., Fox, T.D. Genetics (1993) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.