Disease relevance of Rabep2

• To identify neuronal populations possibly contributing to the sympathetic hyperactivity in rats with congestive heart failure (CHF) after myocardial infarction (MI), immunohistochemical detection of Fra-like immunoreactivity (Fra-LI) was used as a marker of long-term neuronal activation [1].

High impact information on Rabep2

• Fos-like and Fra-like proteins were induced in striatal neurons by activation of D1-like dopamine receptors but not by activation of D2-like receptors [2].
• We analyzed the effects of dopamine receptor agonists and of adenylate cyclase and protein kinase activation on striatal neurons by measuring the induction of Fos-like and Fra-like proteins in the cultured striatum [2].
• A time course study indicated that chronic Fra induction was first apparent after 3 days of morphine treatment and peaked between 5 and 7 days of treatment in both the striatum and nucleus accumbens [3].
• Results from Western blot analysis using an anti-fosB antibody demonstrate that 10-day intermittent escalating dose morphine produced a significant increase in deltaFosB-immunoreactivity in the nucleus accumbens, caudate putamen and frontal cortex, whereas a single injection of morphine had no effect on Fra immunoreactivity [4].
• The goal of the present study was to characterize pharmacologically the regulation of chronic Fra induction by cocaine [5].

Biological context of Rabep2

• One gene, MP13, was cloned with a 1662 bp open reading frame and coded for a 554-amino acid protein [6].
• The binding protein was shown to contain c-Fos/Fra and c-Jun since addition of c-Fos/Fra antiserum formed a supershift of the DNA, protein and antibody complex, and c-Jun antibody blocked the protein DNA binding [7].
• The interaction between glycolysis, glutaminolysis and tumor growth in WAG/Fra rnu/rnu rats has been investigated [8].

Anatomical context of Rabep2

• Cloning and expression of MP13 gene from rat hippocampus, a new factor related to guanosine triphosphate regulation [6].

Associations of Rabep2 with chemical compounds

• MP13 has a leucine zipper region, a glutamine repeat region, and has high similarity to the activator of the small guanosine triphosphate (GTP)ase Rab5 [6].
• Similarly, repeated treatment with a specific dopamine transporter inhibitor increased chronic Fra levels, whereas treatment with a specific serotonin or norepinephrine transporter inhibitor failed to produce this effect [5].

References