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Gene Review

Slc26a5  -  solute carrier family 26, member 5

Mus musculus

Synonyms: Pres, Prestin, Solute carrier family 26 member 5, prestin
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Disease relevance of Slc26a5

  • Results from F3-F5 generation mice suggest that one copy of the prestin gene is capable of compensating for the deleted copy and that heterozygous mice do not suffer peripheral hearing impairment [1].

High impact information on Slc26a5

  • Prestin, a member of the solute carrier family 26, is expressed in the basolateral membrane of outer hair cells [2].
  • We investigated possible quaternary structures of prestin by lithium dodecyl sulfate-PAGE, perfluoro-octanoate-PAGE, a membrane-based yeast two-hybrid system, and chemical cross-linking experiments [2].
  • Chemical cross-linking experiments, perfluoro-octanoate-PAGE/Western blot, and affinity purification experiments all indicate that prestin exists as a higher order oligomer, such as a tetramer, in prestin-expressing yeast, mammalian cell lines and native outer hair cells [2].
  • In addition, both immunocytochemistry and western blot analysis in young adult mice suggest that prestin protein in heterozygotes is near normal [1].
  • Although the cochlear microphonic in knockout mice remains approximately 12 dB below that in wild-type mice even at the highest levels, this deficit is thought to reflect hair cell losses in mice lacking prestin [3].

Biological context of Slc26a5


Anatomical context of Slc26a5


Physical interactions of Slc26a5


Analytical, diagnostic and therapeutic context of Slc26a5


  1. Cochlear function in mice with only one copy of the prestin gene. Cheatham, M.A., Zheng, J., Huynh, K.H., Du, G.G., Gao, J., Zuo, J., Navarrete, E., Dallos, P. J. Physiol. (Lond.) (2005) [Pubmed]
  2. Analysis of the oligomeric structure of the motor protein prestin. Zheng, J., Du, G.G., Anderson, C.T., Keller, J.P., Orem, A., Dallos, P., Cheatham, M. J. Biol. Chem. (2006) [Pubmed]
  3. Cochlear function in Prestin knockout mice. Cheatham, M.A., Huynh, K.H., Gao, J., Zuo, J., Dallos, P. J. Physiol. (Lond.) (2004) [Pubmed]
  4. Genomic characterization and expression of mouse prestin, the motor protein of outer hair cells. Zheng, J., Long, K.B., Matsuda, K.B., Madison, L.D., Ryan, A.D., Dallos, P.D. Mamm. Genome (2003) [Pubmed]
  5. Prestin expression in the cochlea of the reeler mouse. Zheng, J., Richter, C.P., Cheatham, M.A. Neurosci. Lett. (2003) [Pubmed]
  6. Hearing threshold elevation precedes hair-cell loss in prestin knockout mice. Wu, X., Gao, J., Guo, Y., Zuo, J. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  7. Expression of prestin, a membrane motor protein, in the mammalian auditory and vestibular periphery. Adler, H.J., Belyantseva, I.A., Merritt, R.C., Frolenkov, G.I., Dougherty, G.W., Kachar, B. Hear. Res. (2003) [Pubmed]
  8. Promyelocytic leukemia zinc finger protein localizes to the cochlear outer hair cells and interacts with prestin, the outer hair cell motor protein. Nagy, I., Bodmer, M., Schmid, S., Bodmer, D. Hear. Res. (2005) [Pubmed]
  9. Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin. Tian, Y., Li, M., Fritzsch, B., Zuo, J. Dev. Dyn. (2004) [Pubmed]
  10. Prestin is expressed on the whole outer hair cell basolateral surface. Yu, N., Zhu, M.L., Zhao, H.B. Brain Res. (2006) [Pubmed]
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