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RPI2  -  ribose 5-phosphate isomerase A

Arabidopsis thaliana

Synonyms: F10A8.17, F10A8_17, ribose-5-phosphate isomerase 2
 
 
 
 
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High impact information on AT2G01290

  • A mutation in an Arabidopsis ribose 5-phosphate isomerase reduces cellulose synthesis and is rescued by exogenous uridine [1].
  • Although RPI is intimately involved with many biochemical pathways, media supplementation experiments suggest that the visible phenotype results from a defect in the production of pyrimidine-based sugar-nucleotide compounds, most likely uridine 5'-diphosphate-glucose, the presumed substrate of cellulose synthase [1].
  • Two of three RPI sequences in the nuclear genome are cytoplasmic, while the third has a putative chloroplast transit sequence [1].
  • Map-based cloning showed that the mutated gene (At1g71100) encodes a ribose 5-phosphate isomerase (RPI) and that the rsw10 mutation replaces a conserved glutamic acid residue with lysine [1].
  • The prominence of the rsw10 phenotype in roots probably reflects RSW10 being the only cytosolic RPI in this tissue and the gene encoding the plastid RPI being relatively weakly expressed [1].

References

  1. A mutation in an Arabidopsis ribose 5-phosphate isomerase reduces cellulose synthesis and is rescued by exogenous uridine. Howles, P.A., Birch, R.J., Collings, D.A., Gebbie, L.K., Hurley, U.A., Hocart, C.H., Arioli, T., Williamson, R.E. Plant J. (2006) [Pubmed]
 
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